ID A0A1Z5H8H6_9GAMM Unreviewed; 377 AA.
AC A0A1Z5H8H6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=bplSymb_SCF01207P003 {ECO:0000313|EMBL:GAW85789.1};
OS Bathymodiolus platifrons methanotrophic gill symbiont.
OC Bacteria; Pseudomonadota; Gammaproteobacteria.
OX NCBI_TaxID=113268 {ECO:0000313|EMBL:GAW85789.1, ECO:0000313|Proteomes:UP000196430};
RN [1] {ECO:0000313|EMBL:GAW85789.1, ECO:0000313|Proteomes:UP000196430}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HPD1508-B01-01 {ECO:0000313|EMBL:GAW85789.1,
RC ECO:0000313|Proteomes:UP000196430};
RX PubMed=28453654; DOI=10.1093/gbe/evx082;
RA Takishita K., Takaki Y., Chikaraishi Y., Ikuta T., Ozawa G., Yoshida T.,
RA Ohkouchi N., Fujikura K.;
RT "Genomic Evidence that Methanotrophic Endosymbionts Likely Provide Deep-Sea
RT Bathymodiolus Mussels with a Sterol Intermediate in Cholesterol
RT Biosynthesis.";
RL Genome Biol. Evol. 9:1148-1160(2017).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAW85789.1}.
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DR EMBL; BDMN01000098; GAW85789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z5H8H6; -.
DR OrthoDB; 9792276at2; -.
DR Proteomes; UP000196430; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21123; SPASM_MftC-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR023992; HemeD1_Synth_NirJ.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04051; rSAM_NirJ; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR SFLD; SFLDF00393; heme_D1_biosynthesis_(NirJ-lik; 1.
DR SFLD; SFLDG01216; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000196430};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 22..240
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 377 AA; 42863 MW; 745DC96D43881D58 CRC64;
MFRLSQFMRE VLHPTPLKAA RKPAAPVVIW NLIRRCNLTC KHCYTTSADI NFPGELSTEA
IYNVMDDLKA YKVPVLILSG GEPLLHPDIF KISQRAKDMD FYVALSSNGT LITEKNIQKI
AAINYQYVGV SLDGIGKTHD DFRQQQGSFD ASVHGIQLCR EQGIKAGIRF TLTQDNVHDF
PAMLDFMDSK NIDKFYLSHL NYGGRGNKNR KQDAVFSMTR EAMDLLFDKC LQWEKQGQHR
EVVTGNNDAD AVYFLHWVRK NFPEQVAHIQ TRLEQWGGNA SGVNVANIDN LGNVHPDTFW
WHYDLGNVLQ RPFSEIWQDI SNPLMAGLKQ SPRPLKGRCG TCSFQKICNG NTRVRAQQVY
ADAWAEDPGC YLNETEI
//
