ID   A0A1Z5JK94_FISSO        Unreviewed;      1170 AA.
AC   A0A1Z5JK94;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Phosphodiesterase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=FisN_20Hu176 {ECO:0000313|EMBL:GAX14201.1};
OS   Fistulifera solaris (Oleaginous diatom).
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC   Bacillariophyceae; Bacillariophycidae; Naviculales; Naviculaceae;
OC   Fistulifera.
OX   NCBI_TaxID=1519565 {ECO:0000313|EMBL:GAX14201.1, ECO:0000313|Proteomes:UP000198406};
RN   [1] {ECO:0000313|EMBL:GAX14201.1, ECO:0000313|Proteomes:UP000198406}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCC DA0580 {ECO:0000313|EMBL:GAX14201.1,
RC   ECO:0000313|Proteomes:UP000198406};
RX   PubMed=25634988; DOI=10.1105/tpc.114.135194;
RA   Tanaka T., Maeda Y., Veluchamy A., Tanaka M., Abida H., Marechal E.,
RA   Bowler C., Muto M., Sunaga Y., Tanaka M., Yoshino T., Taniguchi T.,
RA   Fukuda Y., Nemoto M., Matsumoto M., Wong P.S., Aburatani S., Fujibuchi W.;
RT   "Oil accumulation by the oleaginous diatom Fistulifera solaris as revealed
RT   by the genome and transcriptome.";
RL   Plant Cell 27:162-176(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAX14201.1}.
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DR   EMBL; BDSP01000076; GAX14201.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Z5JK94; -.
DR   InParanoid; A0A1Z5JK94; -.
DR   OrthoDB; 5479253at2759; -.
DR   Proteomes; UP000198406; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00233; PDEase_I; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198406};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        102..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          562..696
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          795..1018
FT                   /note="PDEase"
FT                   /evidence="ECO:0000259|PROSITE:PS51845"
FT   REGION          750..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1170 AA;  131775 MW;  061ACC9BE49DE607 CRC64;
     MTINRTPDKF VLLLAFAEIG VHRVHLQTDC NKHIPVNQRQ RIIIIMMNDD NDHSWSVDGG
     ESSDGDNHRP YGMDSIEQEK AEEAAVAEIT KRETRGVQMW RVFTIFTLVA VSVAVSTITF
     RLLQNKDVDE FEDSYAFFAA AIQNAIETHI EDVFSAGELV SVQVTKAAME KNESFPFVSV
     DLYEIIGSQA RKMSGVDQII WGPVVDADQY DAWTIYSAEN IGWYKASVEL YMAEPEEDEE
     DDRRLEEYDF SDTNYEISSP AEGQDVGPGP WAPIWQVSPP PPSSSAINLD MYAYGTKALD
     DAVDAFRMGL MTQVIDAESE NKDSPRSVVV EPVFEHLLDD ETAPIVGHIY SLFTWETYFS
     SLLPEGVNGF LAVLKNSCGQ SFTYALNGKS VEFMGVGDMH DTNYDHMETV IPFHDDEASD
     QEELTGVAGH CLYYVSIYPT KDFAQKYNSS DPVQATTTLV FAFAFMITAF LMFDCFVVRR
     NRKLLIAMTR TNAIVSNLFP STVRDRIFAQ AKHENDEKKG LNGKSRLKTF LSDGNDGNDE
     MDENDHFLYK TKPIADLFPE TTILFADLAG FTAWSSMREP TQVFILLETI YKAMDDIAKA
     RRVFKVETVG DCYVAVTGLP DPRKDHAVAM CRFASDCVQK MDALTRKLEV ILGPDTTDLQ
     MRVGLHSGPV TAGVLRGERS RFQLFGDTMN TASRMESNGL PGKIHISQET ARLLIAAGKE
     HWVVPREEKV VAKGKGELQT YWLVTTKASN HAQSDTASSE TETSGEVGGT MLHNTTCEMP
     TPLMDEKTER LVKWNVEVLA ALLKKVISHR SDLVDTQEST QKTSFSKLTT TPLDEVQEII
     RMPVFKGCSV AEIKEEDLGS AVVEQLQEYV SAIASMYQNN PFHNFEHASH VTMSVVKLLS
     RIVAPDVDAV NSDLDSTLHD YTYGITSDPL TQFACVFSAL IHDVDHPGVP NTQLVAENPQ
     LARFYKEKSV AEQNSVDLSW ELLQDNNFKD LRLAICPTEH DRVRFRQLVV NSVMATDIMD
     KDLKNLRNMR WDKAFAAQNA EESMKDAVDR KATIVIEHLI QASDVAHTMQ HWHIYTKWNQ
     RLFEEMYSAY IQGRSATDPS ENWYKGEIGF FDFYIIPLAK KLRECGVFGV SSDEYLNYAE
     KNRHEWEARG IEVVANMVVA VHKKFGTKSR
//