ID A0A1Z5KMT6_FISSO Unreviewed; 649 AA.
AC A0A1Z5KMT6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=formate--tetrahydrofolate ligase {ECO:0000256|ARBA:ARBA00012295};
DE EC=6.3.4.3 {ECO:0000256|ARBA:ARBA00012295};
GN ORFNames=FisN_13Hh315 {ECO:0000313|EMBL:GAX27596.1};
OS Fistulifera solaris (Oleaginous diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Naviculales; Naviculaceae;
OC Fistulifera.
OX NCBI_TaxID=1519565 {ECO:0000313|EMBL:GAX27596.1, ECO:0000313|Proteomes:UP000198406};
RN [1] {ECO:0000313|EMBL:GAX27596.1, ECO:0000313|Proteomes:UP000198406}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCC DA0580 {ECO:0000313|EMBL:GAX27596.1,
RC ECO:0000313|Proteomes:UP000198406};
RX PubMed=25634988; DOI=10.1105/tpc.114.135194;
RA Tanaka T., Maeda Y., Veluchamy A., Tanaka M., Abida H., Marechal E.,
RA Bowler C., Muto M., Sunaga Y., Tanaka M., Yoshino T., Taniguchi T.,
RA Fukuda Y., Nemoto M., Matsumoto M., Wong P.S., Aburatani S., Fujibuchi W.;
RT "Oil accumulation by the oleaginous diatom Fistulifera solaris as revealed
RT by the genome and transcriptome.";
RL Plant Cell 27:162-176(2015).
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAX27596.1}.
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DR EMBL; BDSP01000259; GAX27596.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z5KMT6; -.
DR InParanoid; A0A1Z5KMT6; -.
DR OrthoDB; 651667at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000198406; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00477; FTHFS; 1.
DR Gene3D; 1.10.8.770; -; 1.
DR Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01543; FTHFS; 1.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01268; FTHFS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:GAX27596.1};
KW Ligase {ECO:0000313|EMBL:GAX27596.1};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Oxidoreductase {ECO:0000313|EMBL:GAX27596.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198406}.
SQ SEQUENCE 649 AA; 69563 MW; E4254FA70D5CFCF1 CRC64;
MNTEEELNAL GYPVLKPKTP VPSDIEVSQS IVRDVGLLPI TEVGKQLGLN DDEIIPWGIA
KAKIPLTART NRLDVEDGNY VVVTGINPTP LGEGKSTTTI GLAQALSAVR GKKTVACIRQ
PSQGPTFGIK GGAAGGGYAQ VVPMEEFNLH LTGDIHAVTA ANNLLAAAIE TRLFHEASQS
DEALFKRLTS KPFSAVQKRR LRKLGIDETK PPEEFTPDEK RRFARLDMDP STITWQRVLD
TCDRHLRTVE VGLGAQETVK SGSERVQHSR RTGFDITVAS EVMAVLALST DLHDMREKLG
AMVVAYNKQG EPVTADDLGC GGAMTVLMKD AIMPTLMQTV ERSPVFVHAG PFANIAVGNS
SIIADAIALK VVGPDGFCVT EAGFGADIGM EKFFNIKCRA SGLKPKCAVI VATVRALKMH
GGGPPVAAGQ PLSIEYQQEN VELVEKGTSN LIRHIENAKK YGVNVVVAVN QFKTDTLAEI
EAIRTNALQA GAFAAVVSNH WAEGGKGAAA LAEAVEQACA DSQTENFRLL YESSKSIQEK
IEIICKEMYR ADGVDYSPTA QAQIEQYEKS GFGHLPICIA KTQYSFSCDA SAKGAPTGFR
VPVREVRSCV GAGFLYPICG DIMTIPGLST RPGFMDVDIS ESGEVIGLF
//
