ID A0A1Z5RGT2_SORBI Unreviewed; 905 AA.
AC A0A1Z5RGT2;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Cation chloride cotransporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=SORBI_3005G040700 {ECO:0000313|EMBL:OQU82897.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:OQU82897.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:OQU82897.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM000764; OQU82897.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z5RGT2; -.
DR EnsemblPlants; OQU82897; OQU82897; SORBI_3005G040700.
DR Gramene; OQU82897; OQU82897; SORBI_3005G040700.
DR Proteomes; UP000000768; Chromosome 5.
DR ExpressionAtlas; A0A1Z5RGT2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF68; CATION-CHLORIDE COTRANSPORTER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..560
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 601..696
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 706..904
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 99280 MW; 7493E8715ACA98AE CRC64;
MKPSANQSVD PRTQMASSNG HAVSNVSQSD SKLELFGFDS LVNILGLKSM AGEQAQAPSS
PRDEDVEIAI GFPKETEPKQ GTLMGVFIPC LQNILGIIYY IRFTWIVGMG GIWQSLVLVA
FCGACTFLTG LSLSAIATNG AMKGGGPYYL IGRALGPEVG ISIGLCFFLG NAVAGAMYVL
GAVETFLDAI PSAGFFQETV TVVNNTLGNG TTKSATTIST PSLHDLQIYG VIVTILLCFI
VFGGVKIINK VAPAFLVPVL FSILCIYIGV SIAPEPGAPK GITGLSIVTL AENWSSEYQP
TNNAGVPDPN GSIYWDFNAL LGLFFPAVTG IMAGSNRSAS LKDTQRSIPI GTLSATLSTT
LMYLLSVFLF GALATREELL TDRLLAATIA WPGPAVIYIG IILSTLGAAL QSLTGAPRLL
AAIANDDILP ILNCFKAYEG SEPHVATLFT SFICIACVVI GNLDLITPTI TMFFLLCYAG
VNLSCFLLDL LDAPSWRPRW KIHHWVLSLI GASQCIVIMF MISWTFTVVS LALASLIYYY
VSLKGKAGDW GDGFKSAYFQ LALRSLRSLG ANNVHPKNWY PIPLIFCRPW GKLPENVPCH
PKLADFAKCM KKKGRGMSIF VSIIDGDYHE SAEEANTAYR QLSAYIDYKH CEGVAEIIVA
RSISDGFRSI VQIMGLGNLK PNIVVMRYPE IWRRLDEWPN EYQRLYGTID LYWIVRDGGL
MLLLSQLLLA RNGFESCKIQ VFCIAEEGTE AEELKADVKK YLYDLRMQAE VIVVTMKSME
AHSEISPNAK KDPQEEYTSA QDRIRAYLSQ TKETAQREGR PLMEDGRQVV VNEEKVEKFL
YTMLKLNTTI VKYSMMAAVV LVSLPPPPLN HPAYCYMEYM DMLVVNVPRI LIVRGYKRDV
VTLFT
//
