ID A0A1Z5SLI1_HORWE Unreviewed; 1453 AA.
AC A0A1Z5SLI1;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=BTJ68_15575 {ECO:0000313|EMBL:OTA19079.1};
OS Hortaea werneckii EXF-2000.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX NCBI_TaxID=1157616 {ECO:0000313|EMBL:OTA19079.1, ECO:0000313|Proteomes:UP000194280};
RN [1] {ECO:0000313|EMBL:OTA19079.1, ECO:0000313|Proteomes:UP000194280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-2000 {ECO:0000313|EMBL:OTA19079.1,
RC ECO:0000313|Proteomes:UP000194280};
RA Sinha S., Flibotte S., Neira M., Lenassi M., Gostincar C., Stajich J.E.,
RA Nislow C.E.;
RT "The recent genome duplication of the halophilic yeast Hortaea werneckii:
RT insights from long-read sequencing.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OTA19079.1}.
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DR EMBL; MUNK01000472; OTA19079.1; -; Genomic_DNA.
DR STRING; 1157616.A0A1Z5SLI1; -.
DR VEuPathDB; FungiDB:BTJ68_15575; -.
DR InParanoid; A0A1Z5SLI1; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000194280; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000194280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1453
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012757860"
FT TRANSMEM 1318..1339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1381..1402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..677
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 680..1307
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 1161..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1453 AA; 163367 MW; 810F948E17FCBEBC CRC64;
MHMSMARILG VLVALLALTV SAKKKDKPSV EETKFDSPQN LFYFEDSDVV LVTDTSERIA
YRSEDAGVHW APLEDVKKGE VLEVINHPWN NQMAIVLGMN KKHWITRDQG KSWKAFELPE
KPTLARPPIA FHATDSERLI VLTASCQSFE CKESAYYTLD GFDSKPKLLL DDAMSCLWAK
STDLLQTDED DILCVVQGTF SPWSSDYKLL LSSDFFETDG VEPAMTEDGR PVSGIMNVAS
VKSYLVAAAK SENTRELAMF VTADAKHWHR AEFGEHKLEE DAYTLLESTN YSMQVDVLTT
KPSVPMGVLL TSNSNGTFFT KNIEHTNRNM HGFVDFEKIQ NIQGIVMVNT VDNWEDVEKK
WLADKKIRTQ ISFDDGRTWQ PMKVDDKDLH LHSVTNQRNM GRIFSSPAPG IVMGVGNTGK
HLKAYDEGDL FVSDDAGLTW MKALSRPHLY EFGDQGAILV AIEDEETDEI KWSLNHGKDW
TTIELSDLDI KGKIKPTGLT TTPDSTSLKF LLSATKGKGS KLQHFVYSIN FEGLHEKQCK
TDDFEQWYAR VDEDGEPSCI MGHTQMFRRR KADAECFVDE EFKDPVPKME DCKCKEVDFE
CDYENNFTWD ADKEKLIPGN TCTKEGGEKL DEPVERDCDK APEESRPSGK IASEVTHFKG
ERFAEYYYLE RCPDCSGTDE TVVMRTDRRD AWLSRDHGIK WEKIDTDGEE VVAIYPHQYL
NDVVYLVTPS KTVFYSQNRG DKWHSFDAPE KPNQDHLQIL QFHPTQKDWL IWTGHAKDQT
IAHVSTKGGD DWETLLRSVR KCQFVYREDR PESDQLIFCE QYESEDSAAP ISLFSSDDWF
EHKKELKRDV INFATMAEYI VVASRDSDEK SLKVDTSIDG QMFADAKFPT NFKVPHQQAY
TVLDSSTHAV FLHVTVNNQM DSEYGSIVKS NSNGTSYVLS VGEVNRNSPG YVDFEKMQGL
EGVAVVNRVA NPKEADNGKM KKLKTYITHN DGADWALIPK PEKNVNGKNF KCKGGIEKCS
LHLHGYTERK DPRDTFSSPS AVGLMIATGN VGQFLGAKKE AGTFATRDGG VTWTQIAEGN
WMWEFGDQGS ILVIVKEDEP TDSVLYSLDE GVTWERFAFT ESSMQVEDIT TVPSDTSRRF
LLWGKIKGEL ASVNLDFTGL EERSTPCESP DRPGAEGQSK DYDLWEPKHP LSDDNCLFGH
VAQYHRKKLN ANCYNGREIQ HLHSIARNCT CTRRDFECDY NYEKQTDGSC ALVPGLSPPD
PQDQCKNDGV DEYFDVTGYR RIPLTTCQGG QELDYTSRVS PCPGKEAEFE RKHGISGAGL
FFAIVIPIAA AAGVGYWVWK NWDGKFGRIQ LGGDTPSMGL GGGGGYGGAF DRDAPWIKYP
VMALSGVVAV VAALPMVANS LWRTISTRLG RNRAGGYSRP YTSRSSFSRG RGDYAVVDPD
EGELLGEESD DEV
//
