ID A0A1Z5SMK8_HORWE Unreviewed; 764 AA.
AC A0A1Z5SMK8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=cellulase {ECO:0000256|ARBA:ARBA00012601};
DE EC=3.2.1.4 {ECO:0000256|ARBA:ARBA00012601};
GN ORFNames=BTJ68_14754 {ECO:0000313|EMBL:OTA22082.1};
OS Hortaea werneckii EXF-2000.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX NCBI_TaxID=1157616 {ECO:0000313|EMBL:OTA22082.1, ECO:0000313|Proteomes:UP000194280};
RN [1] {ECO:0000313|EMBL:OTA22082.1, ECO:0000313|Proteomes:UP000194280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-2000 {ECO:0000313|EMBL:OTA22082.1,
RC ECO:0000313|Proteomes:UP000194280};
RA Sinha S., Flibotte S., Neira M., Lenassi M., Gostincar C., Stajich J.E.,
RA Nislow C.E.;
RT "The recent genome duplication of the halophilic yeast Hortaea werneckii:
RT insights from long-read sequencing.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of (1->4)-beta-D-glucosidic linkages in
CC cellulose, lichenin and cereal beta-D-glucans.; EC=3.2.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000966};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 9 (cellulase E) family.
CC {ECO:0000256|ARBA:ARBA00007072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OTA22082.1}.
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DR EMBL; MUNK01000405; OTA22082.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z5SMK8; -.
DR STRING; 1157616.A0A1Z5SMK8; -.
DR VEuPathDB; FungiDB:BTJ68_14754; -.
DR InParanoid; A0A1Z5SMK8; -.
DR OrthoDB; 2100839at2759; -.
DR Proteomes; UP000194280; Unassembled WGS sequence.
DR GO; GO:0008810; F:cellulase activity; IEA:UniProtKB-EC.
DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR CDD; cd02850; E_set_Cellulase_N; 1.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR004197; Cellulase_Ig-like.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001701; Glyco_hydro_9.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR22298; ENDO-1,4-BETA-GLUCANASE; 1.
DR PANTHER; PTHR22298:SF29; ENDOGLUCANASE; 1.
DR Pfam; PF02927; CelD_N; 1.
DR Pfam; PF00759; Glyco_hydro_9; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Cellulose degradation {ECO:0000256|ARBA:ARBA00023001};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW Reference proteome {ECO:0000313|Proteomes:UP000194280};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..764
FT /note="cellulase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013369195"
FT DOMAIN 173..255
FT /note="Cellulase Ig-like"
FT /evidence="ECO:0000259|Pfam:PF02927"
FT DOMAIN 266..758
FT /note="Glycoside hydrolase family 9"
FT /evidence="ECO:0000259|Pfam:PF00759"
FT REGION 698..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 83628 MW; 0F801AF3C150DF78 CRC64;
MQSWWLFVSI LASPAISQVA DPPIPGTPQI IRNGNFINGS SGWTSSPEGQ VADGSYCVRV
PKGQGFNVSY LRTTYDFLET KNDIYTLNFT ASSSVGYDIR VQTPDPPLDP NLDMKAALTT
SPYPFSMTFS PANQAPNATL EFNLGGSPAD ALVCIGSVSM KRIDRSGWQQ DLGPAIKVNQ
LGYLANGPKM ATLVTNNMTT AQPWALHDRS GKVCFEGQTE YLGMDAASNQ TVSKIDFTSF
NSTGEGYTLV SAGDTSFEFK ISTSVYNDLQ QDALRFFYLQ RSGIEIDGNL VGQKYARPPG
HLQIPPNKGD LIVPCQVVHD SLIAYEEPWT CNYTLDVTQG WYDAGDQGKY VVNGGISAAQ
LLMAYERRSR YDSHGKPTPS EDGSLRIPER HNEIPDILDE ARWELDFLLK MQVPESSPPQ
LFNGTMIDMS SLAHHKMHDN EWTPLPTEPS QDPKRRELHR PSTAATLNLA AVAAMGARIF
ADFDATYAER CLYAAQTAYT AARRHPNILA PGTDWDLGGG AYSDDDVSDE FYWAAAEMYL
TTSSPDYLAD LRENPYHTAN ASTAFSIPSG FSWGSVAALG RLDLAMHLNE TSSEKDRLVQ
SVMDAADMLI EVQQNQSNGY DVFITEYQWG SNSNHLNNLQ VVATAADISN NKTYRDAALR
GLDYTLGRNA LAQSYVCGYG TKVPQNLHSR LYAHQLDDSV PRAPPGSMAG GANENASDPP
ADDVLQGCAP QTCYVDDVNS YSTNEVAINW GSALAWVVNW AATQ
//
