ID   A0A1Z5SP30_HORWE        Unreviewed;      1246 AA.
AC   A0A1Z5SP30;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=BTJ68_14295 {ECO:0000313|EMBL:OTA22579.1};
OS   Hortaea werneckii EXF-2000.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX   NCBI_TaxID=1157616 {ECO:0000313|EMBL:OTA22579.1, ECO:0000313|Proteomes:UP000194280};
RN   [1] {ECO:0000313|EMBL:OTA22579.1, ECO:0000313|Proteomes:UP000194280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EXF-2000 {ECO:0000313|EMBL:OTA22579.1,
RC   ECO:0000313|Proteomes:UP000194280};
RA   Sinha S., Flibotte S., Neira M., Lenassi M., Gostincar C., Stajich J.E.,
RA   Nislow C.E.;
RT   "The recent genome duplication of the halophilic yeast Hortaea werneckii:
RT   insights from long-read sequencing.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OTA22579.1}.
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DR   EMBL; MUNK01000359; OTA22579.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Z5SP30; -.
DR   STRING; 1157616.A0A1Z5SP30; -.
DR   VEuPathDB; FungiDB:BTJ68_14295; -.
DR   InParanoid; A0A1Z5SP30; -.
DR   OrthoDB; 154387at2759; -.
DR   Proteomes; UP000194280; Unassembled WGS sequence.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   CDD; cd07230; Pat_TGL4-5_like; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 2.
DR   Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF10; TRIACYLGLYCEROL LIPASE 4-RELATED; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000194280}.
FT   DOMAIN          148..345
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   1246 AA;  137395 MW;  EA854A47C3E52C1F CRC64;
     MITGSDEREQ QLGRLRTAKT AEEWRAAALE LDRLEGRNKW KEVDETEEEE YDPKLIRARL
     QRLQDAVERG DIEDMRFQIR TALTRDLGGM GNVRLYRHCH IGTKSLIEKY IETVSLAIDA
     VVETSGLEPR LVGELMKHTR QAFGRSALLL SGGGTLGMNH IGVVKALFEA RVLPRIISGA
     SAGSIVCSVL CTKTDEEMPA VLEEFAESDL GVFEKIDEPA KLTTAIKRLL TKGVIYDIGN
     LKRVMRGLLG DLTFLEAYNR TQRILSICVS SASAFEAPRL LNYVTAPDVV IWSAVAASCS
     VPLVFNPTDI LAKDRSTGIV DKWDEEGGRW IDGSVDNDLP MTRLAEMLNV NHFIVSQVNP
     HVVPFLSKEE DELATDASRS SPSFVPGPGW MSTMANLAKG EALHRLHVMS ELGLWPTMTT
     KIRSVLGQRY AGDITILPEI SYTQFPYILS NPTKDFMEQA LFNGERATWP KISRIRNHLA
     IELKLDEAVR KMTRKIAFSS SQVDLRMNQF QRSPTAARTG KKLSRHGTSA LFISINTLSP
     FVHVPGLGNP EVINIMEKDD LPRYSTSDEY AALRQRREWR KRILRLAVLV AFGFALFQWS
     SDTNNPKSMS DQALLSKERL NADYATCSKL RHTPQDPSGP REANARWQQS QKPVLIRNAT
     VWTGEALASS SSQDASSDET YTWIHADVYL EKGLIQRVEP GISPSSLAAD YETWDAKGRL
     LTAGIVDIHS HAGVDTLPEL NWRYMKCACG ENAKRVYGEV GRDYGPFSRM GEAYYFRHAF
     EQASNLVRTQ DDWCDAADRL GAENMPKYLP APLEWETLAA ALRGQVMVNT HCYTIPDLEA
     FVRHTNEFNF SVRAFHHAHQ TYLVPEILKR AYGDRPPAAA LFADNMYYKA EAYIASEQAG
     KVLYENGITP VFLGLVEIAA EEDTQDGSND DSTFSAALDG LSMQGKSLAA AYSHGVTRAI
     SAPASSGEGR KGVSVGFRTG AKHSLEEGAV WEDEVAVHYT LTLGAKTEKT PSLSSAVDAL
     RRKLLKAVKD GKKDDQGVLS LEDAKLKQVV KGEMPLVLDV HSADTIASLL RMKIDIESAM
     RPGTDSADRT LRLILFGGAE SHLLAEELAT ANVSVILAPL LPYSETWEQR RSLTGAPLTN
     GTAVDVLHAA GVQVAISTKE DWETRDLGLM AGIARANSDG KISEDEAWSM VSSNIYAMLG
     LDSLGLGSTG ATAGDTEFVV YDGNPLEIDS RLRVVADGRG EVTVWT
//