ID   A0A1Z5SYP5_HORWE        Unreviewed;       712 AA.
AC   A0A1Z5SYP5;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=VASt domain-containing protein {ECO:0000259|PROSITE:PS51778};
GN   ORFNames=BTJ68_11709 {ECO:0000313|EMBL:OTA26648.1};
OS   Hortaea werneckii EXF-2000.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX   NCBI_TaxID=1157616 {ECO:0000313|EMBL:OTA26648.1, ECO:0000313|Proteomes:UP000194280};
RN   [1] {ECO:0000313|EMBL:OTA26648.1, ECO:0000313|Proteomes:UP000194280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EXF-2000 {ECO:0000313|EMBL:OTA26648.1,
RC   ECO:0000313|Proteomes:UP000194280};
RA   Sinha S., Flibotte S., Neira M., Lenassi M., Gostincar C., Stajich J.E.,
RA   Nislow C.E.;
RT   "The recent genome duplication of the halophilic yeast Hortaea werneckii:
RT   insights from long-read sequencing.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the YSP2 family.
CC       {ECO:0000256|ARBA:ARBA00006582}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OTA26648.1}.
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DR   EMBL; MUNK01000186; OTA26648.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Z5SYP5; -.
DR   STRING; 1157616.A0A1Z5SYP5; -.
DR   VEuPathDB; FungiDB:BTJ68_11709; -.
DR   InParanoid; A0A1Z5SYP5; -.
DR   OrthoDB; 45896at2759; -.
DR   Proteomes; UP000194280; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR031968; VASt.
DR   PANTHER; PTHR23319:SF4; AT22714P-RELATED; 1.
DR   PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF16016; VASt; 1.
DR   SMART; SM00568; GRAM; 1.
DR   PROSITE; PS51778; VAST; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000194280};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        580..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          354..526
FT                   /note="VASt"
FT                   /evidence="ECO:0000259|PROSITE:PS51778"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          524..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..64
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..276
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..555
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   712 AA;  77220 MW;  67216738DA114B84 CRC64;
     MKKPVHNAVS QATGRPMSVT SQDRLTLAGD QTPPRSTADG DGLRRSGSVR SRLSGRRRHR
     ASSATTGTHH TTATNGAIAA AIQSSASTLA IPNTNAVGGG HRMTGFAVAS SKRNKDFHAL
     FRSVPEDDYL IEDYSAALQR DILLHGRLYV SEGHICFSSN ILGWVTNLVI SFDEVVSVEK
     RNTAIVFPNA IAIQTLHAKN TFASFVARDS TYELLIGIWK ISHPNLKSSL NGVTVENAAQ
     GDKTEVVDAA DEDDGASAGG SEDEVYDEDD EDEVGSFSDA AAPSIGGSDA DGAPLSRKTS
     AVPVGAMTQQ NGIGGARVIE AVDMAAAPAP AGVVDFPGPA THVPTECTDV AEHYDRPITD
     ATIPAPLGKV YSLMFGPASG NFMKKWLVED QKSRELNYAD DKFGLDNDHK SITFDYIKPL
     NGSIGPKQTK CITTNTLLAF DLERAVTIDC STQTPDVPSG NVFTTKTRYC LMWAPGNATR
     LVATCTIEWT GKSWLKGPIE KGANDGQIDY VNSLIASLKA AVSSKPTAKG GPKRGKRKLK
     KGNANDDAVT AKESPVAEKK RTDWGMLEPL HQILEPLHAL LGPFINSQVV IAVLFALLIY
     TWVIPPRPGT NVGMPGYSTP QRLAAYEELW RREESELWDW LEDRVGLDHM YAPDNAMRED
     RQKVLNARGM GRRLEDESMN EHQMDEAVRI TEERLSALKE AIARKRAKRQ EV
//