ID A0A1Z5TDG8_HORWE Unreviewed; 1285 AA.
AC A0A1Z5TDG8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=BTJ68_05915 {ECO:0000313|EMBL:OTA34087.1};
OS Hortaea werneckii EXF-2000.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX NCBI_TaxID=1157616 {ECO:0000313|EMBL:OTA34087.1, ECO:0000313|Proteomes:UP000194280};
RN [1] {ECO:0000313|EMBL:OTA34087.1, ECO:0000313|Proteomes:UP000194280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-2000 {ECO:0000313|EMBL:OTA34087.1,
RC ECO:0000313|Proteomes:UP000194280};
RA Sinha S., Flibotte S., Neira M., Lenassi M., Gostincar C., Stajich J.E.,
RA Nislow C.E.;
RT "The recent genome duplication of the halophilic yeast Hortaea werneckii:
RT insights from long-read sequencing.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OTA34087.1}.
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DR EMBL; MUNK01000065; OTA34087.1; -; Genomic_DNA.
DR STRING; 1157616.A0A1Z5TDG8; -.
DR VEuPathDB; FungiDB:BTJ68_05915; -.
DR InParanoid; A0A1Z5TDG8; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000194280; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000194280};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1285
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012148096"
FT TRANSMEM 267..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1184..1213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1225..1248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..770
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1285 AA; 140424 MW; 067A1C73600628CC CRC64;
MRVASWISIW SSLAATTIAA SSPDLTTKHE AGRCAIRGHC GSQSLFGSQL PCPDNGLAKE
PSPDVRDSLV SLCGDRWADT KVCCEQEQIE ALQSNLQKAQ NIISACPACK QNFFDLFCTF
TCSPDQSLFV NVTETLPKND KFLVTELDHL VSDEYGAGFY DSCKDVKFGA TGGKAMDFIG
GGAKNYTQLL KYLGDKKPFL GSPFQINFPR PDSKDFDGMR TVLDDPKACN SQDERYRCAC
VDCEAACPSL PAVEQKKECH VGLLPCLSFG VIVVYAIFVT LLVLAVSGHV AAAKHRKSKN
ERLQLLQDTV PEDEEDEGAA ITRSGFVERP TKQYFLNTYC DRAFSGLART CANFPAITIG
SSIVVVGLLS LGWLRFAVET DPVKLWVAPD SDAAQEKNFF DKNFGPFFRA EQAFLVNDTN
PNGEAGPVLS YETLRWWFDV EDRVAKIKTP EHGYTFDDVC YQPTGEACVI QSVSQYFQGD
FDMLEPDDWA DQIQDCVDTP VNCLPAFGQP LVIERLLGGY NYSTEPITKA QALVTTWVVS
NHIPGDPELE KAEEFEESLK NLLLDVQEEA KERGLRLSFN TEISLEQELN KNTNTDAKIV
VVSYIVMFIY ASLALGSTTV TTSMVLRNPA AALVQSKFLL GIVGILIVLM SVAASVGLFA
AAGVKATLII AEVIPFLVLA VGVDNIFLIV HEFERVNISH ADEPVSERVA RALGRMGPSI
LLSATTETVA FALGAAVGMP AVRNFAAYAA GAVFINAILQ VTMFVSVLAL NQERVEAGRA
DCIPCLQVKG GTDSGMPHGY GGAPFSGMDE EGWLSRFIRK HYAPTILENK MRVFIMTVFL
GFFAAGIALL PEVPLGLDQR IAIPSDSYLI NYFNDLYDYF GAGPPVYFVT KGVNATQRVH
QQELCGRFST CKEFSLANVL EQERKRPEIS YISDATASWI DDYFGWLNPD LDSCCVDEDG
STCFADRDPA WNVSMYGMPE GQEFVDYMVR WLESLTTAEC PLAGQAPYGD AVVLNRNKTS
TPATHFRTAH TPLRSQDDFI QAYAAARRIA KGINAENPGL EVFPYSKFYI FFDQYATIVK
LSTALVGAAL AFILLISSTL LGSLATGLVV TVTVAMIVVD IVGTMALVGV SLNAVSLVNI
VICVGIGVEF CAHIARAFTI PAPSILDRAS PAKFALNADR SARAFAALVN VGASVFSGIT
VTKLLGVFVL AFTRSKIFEI YYFRVWLALV LWAALHALVF LPVALSFFGG RGYVDPEGDG
GLEQDLASRR YRALLPEDEY DSDDY
//
