ID A0A1Z5TML1_HORWE Unreviewed; 840 AA.
AC A0A1Z5TML1;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
GN ORFNames=BTJ68_02733 {ECO:0000313|EMBL:OTA37235.1};
OS Hortaea werneckii EXF-2000.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX NCBI_TaxID=1157616 {ECO:0000313|EMBL:OTA37235.1, ECO:0000313|Proteomes:UP000194280};
RN [1] {ECO:0000313|EMBL:OTA37235.1, ECO:0000313|Proteomes:UP000194280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-2000 {ECO:0000313|EMBL:OTA37235.1,
RC ECO:0000313|Proteomes:UP000194280};
RA Sinha S., Flibotte S., Neira M., Lenassi M., Gostincar C., Stajich J.E.,
RA Nislow C.E.;
RT "The recent genome duplication of the halophilic yeast Hortaea werneckii:
RT insights from long-read sequencing.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family.
CC {ECO:0000256|ARBA:ARBA00010896}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OTA37235.1}.
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DR EMBL; MUNK01000022; OTA37235.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z5TML1; -.
DR STRING; 1157616.A0A1Z5TML1; -.
DR VEuPathDB; FungiDB:BTJ68_02733; -.
DR InParanoid; A0A1Z5TML1; -.
DR OrthoDB; 4638766at2759; -.
DR Proteomes; UP000194280; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR24341; HOMEOBOX PROTEIN ENGRAILED; 1.
DR PANTHER; PTHR24341:SF6; HOMEOBOX PROTEIN INVECTED-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000194280}.
FT DOMAIN 56..110
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 58..111
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 105..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 91250 MW; 2751B32558F9545F CRC64;
MFRGPAMETF MDFARPAGFH DAGENDQAHY YSAAAAPMGD PTKTSYIQQQ VPCDIKPRLT
KEQHDVLEAE FQRQHKPNTI TKKRFAEVLG VSLDKVNNWF QNRRAKSKHD ARKQQEQFQV
FPQHQSNSQV AYSSDSEISP AYPAQDYCNV MQQFGANDMN SRLDIPRSQQ FPQPALDTFP
NLGGNGSADH FHNMGIQAQQ DNNMFDSPQE MNRRTLTQEQ FDAFAQGGLQ GSDQYSFLQP
NVSGGHDFLN DCFPELQGAD GKLQQGYMFS GDIPAPMSSH DSSIPSSLSD NSISGFPVNA
SMQAGSVGSA DSSEWDGSRS SSIHQEEPFL NIQPHQTSQP AQSASQWQPG QSVPVDPYAL
NQEFKKVAES RQFTQQSQLH EQPLAWPDEA FGHRDSSASL LAHSMSNVGL HTPQPVQNST
FRSPAPPTNI AARRQRPRPA GLHLGGMRTQ SYNSAVQPGS PGQLQPQNTA PAQPLRRIRS
SNVINNGVAQ GRVQKGAGAS QRSPLAWTFS DAIHSPKAVR HASAQAGSGS LAPPTPMSPR
EFPRTQVPAW QASGQAVRQP SINETDLEHS VNFAPLAPVP TQSSTSPPTT PMYHQQNLVQ
QRVGNNVITE NTPPQSAPAS QQSFSTNGFG PPPPQQVHAQ PSSQVQAPPP QPSFATPPQH
QFMSVLFPEQ SYQAPGGSLA PHAQFGAPAQ NTTAGLAAQY PHGVPIVNDS GEIQMMMTHQ
LPFTQLQAPI QHQQMSAPAG QYGMFATSVP QPPMQVTAAV PKQPTQPASD FFVHEYSPPQ
DLKRTATPRK STAENSGPKN YTFANQTPEH FEKGMKKAEP KSNSTSSSSP ASSNGAGHPS
//
