ID A0A1Z8L8D2_9PROT Unreviewed; 348 AA.
AC A0A1Z8L8D2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:OUT45210.1};
DE Flags: Fragment;
GN ORFNames=CBB73_03015 {ECO:0000313|EMBL:OUT45210.1};
OS Pelagibacteraceae bacterium TMED13.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC Candidatus Pelagibacteraceae.
OX NCBI_TaxID=1986627 {ECO:0000313|EMBL:OUT45210.1, ECO:0000313|Proteomes:UP000196466};
RN [1] {ECO:0000313|EMBL:OUT45210.1, ECO:0000313|Proteomes:UP000196466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED13 {ECO:0000313|EMBL:OUT45210.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter
CC family. {ECO:0000256|ARBA:ARBA00025753}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUT45210.1}.
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DR EMBL; NHBS01000018; OUT45210.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z8L8D2; -.
DR Proteomes; UP000196466; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR045016; NhaD-like.
DR NCBIfam; NF038006; NhaD_1; 1.
DR PANTHER; PTHR43269; SODIUM/PROTON ANTIPORTER 1-RELATED; 1.
DR PANTHER; PTHR43269:SF2; SODIUM_PROTON ANTIPORTER 1-RELATED; 1.
DR Pfam; PF03600; CitMHS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..348
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013006947"
FT TRANSMEM 42..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..347
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
FT NON_TER 348
FT /evidence="ECO:0000313|EMBL:OUT45210.1"
SQ SEQUENCE 348 AA; 37994 MW; 1F858367E7A79E96 CRC64;
MNFFTKIFSK FPIFLLALIS PSLVFAASND GPATLDLISS PIGIACLLLF VIAYGFVMAE
EFTHFRKSKP VILAATAIWA MIAFYASTDP GLSAHWAEGK FKHLILEFAE LFFFLFVAMT
YVNALTERKM FDALCAWLSN NNFSYKKIYV ITGVIAFFLS PIADNLTTAL ILGTVVTVAG
RGNKAFIVPA LINIVVSANA GGAFSPFGDI TTLMVWQRGF VSFFDFFNIF LPSVVNYVIP
AAIIYFAIPN EVPKGDGKKV TIQPGGNVIA ALGILTISIT VAGHQVLHMP PVFGMMFGLG
MLGTYGYFLK TRYPGKNKFD IFELTGKAEW DTLLFFYGIL VCVGGLAA
//
