ID   A0A1Z8LE43_9FLAO        Unreviewed;       667 AA.
AC   A0A1Z8LE43;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Penicillin-binding protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CBB74_00935 {ECO:0000313|EMBL:OUT47284.1};
OS   Owenweeksia sp. TMED14.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Owenweeksiaceae;
OC   Owenweeksia.
OX   NCBI_TaxID=1986609 {ECO:0000313|EMBL:OUT47284.1, ECO:0000313|Proteomes:UP000196006};
RN   [1] {ECO:0000313|EMBL:OUT47284.1, ECO:0000313|Proteomes:UP000196006}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMED14 {ECO:0000313|EMBL:OUT47284.1};
RA   Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT   "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT   for marine microbiology.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUT47284.1}.
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DR   EMBL; NHBT01000005; OUT47284.1; -; Genomic_DNA.
DR   Proteomes; UP000196006; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          56..193
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          262..570
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   667 AA;  75417 MW;  AB8E7ED7CA947E6D CRC64;
     MMTDKYESSI RKMAWLVIFT GVVAFIILFK LYFISFSLGP DLIVTAREKV IQERQVPASR
     GNIYSSDGQL LATSMPVYEL RWDAAVMDPL RFKSEVKKTS KALSDLFGIQ AKTQKYWEDY
     LRKTFRAKKR YAFLIKNISY TEYQKVKKMS LFRGNKYKTG LIAHEKYTRL MPLGVLAKRT
     IGYVRGNSXV GLESSFNHVL KGNYGKRWMQ NFGGNQWKPI DSDFSTPPVN GKDIVTTINS
     RIQDIAHKSL IEQLKKFNAD HGCVIVMEAS SGKIRAMVNL GKTDKDEIYR ELRNYAVWEK
     SEPGSTFKVA ALLVALEDGK VDTAQKVDTK GGTYTIYGRK VKDSKKDGYG LISLGRALEL
     SSNTGIVKAL YPEYKNNPKE FIDRMYQIGL ADKSKIQIPG ESIPFIPEPG TSKWNGLSLP
     WMLFGYGVEN TPLQTLMFYN AIANNGTMVN PTIWEATRDH GLIIKNHETM IAHPSIASRD
     NINQIKDLLE KAVRRGTAKN IYSDSLEIAG KTGTSQLNYW DPEKKGYQAS FAGYFPAKNP
     EYSCIVVINR PEISTGFYGN IVAAPVFKDI AMSIHKMTPQ INTPMQGYWD DAIQLVTQQN
     ESEASSKFIR AAEKLEEGKI PNIIGWKSID AIELFENKKW EIKLQGNGAV IDYKVEKPQK
     KILIRLG
//