ID   A0A1Z8V0W5_9PROT        Unreviewed;       570 AA.
AC   A0A1Z8V0W5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Penicillin-binding protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CBC12_03155 {ECO:0000313|EMBL:OUU52843.1};
OS   Candidatus Puniceispirillum sp. TMED52.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; SAR116 cluster;
OC   Puniceispirillum.
OX   NCBI_TaxID=1986639 {ECO:0000313|EMBL:OUU52843.1, ECO:0000313|Proteomes:UP000195809};
RN   [1] {ECO:0000313|EMBL:OUU52843.1, ECO:0000313|Proteomes:UP000195809}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMED52 {ECO:0000313|EMBL:OUU52843.1};
RA   Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT   "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT   for marine microbiology.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUU52843.1}.
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DR   EMBL; NHDF01000057; OUU52843.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Z8V0W5; -.
DR   Proteomes; UP000195809; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        33..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          70..180
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          230..524
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   570 AA;  62076 MW;  66C6227133872C8A CRC64;
     MEDRMNVLSR LIRLISDMPA AEARRVAASR LGVVRIVALC CFCAIGLRVG WLAIDLSSEA
     KAYTPTIKQS VRGDILDRNG QVMATTVPVF ELYADPQEIL DPREAAAKLA TVLTDMDEET
     IYKRITRDTR YAELAWRLSP KKYADVLRLG VAGIHGRRKL TRAYPNATAA AHVLGGVNKD
     GQGIAGIEHH QNTLLASGTD LTLSIDLNIQ AILREEISSQ IDLFEAIGGA GIIQDIETGE
     IIAMVSLPDY NANHMGYIAD DHRFNRATKG LYELGSTFKV MNTAMALESG IFAETDMIDV
     ISTLRVGRHI IDDYHPEKAN LNVAEVLIVS SNKGSARIAD KLGADIQKHF LNELGFFEKT
     ALELPELGMP LIPSRWGRAE IMTISYGHGI SVTPVHLTSA IATTAGSGLL VTPTLIKQSQ
     PAEINVQVFS PQTAAKIRAM MRRVVSHPRG TANKADVNGY LVAGKTGTSE KISGNGYDTK
     ANITSFVSVF PANDPKYVVF TMIDEPKGQK HSYNFATAGW VAAPVAGRII KRVAPMLGVH
     PIDENMPEIR QSLMLNLPEL EKEGAKHASF
//