ID A0A1Z8VD00_9PROT Unreviewed; 329 AA.
AC A0A1Z8VD00;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=biotin--[biotin carboxyl-carrier protein] ligase {ECO:0000256|ARBA:ARBA00024227};
DE EC=6.3.4.15 {ECO:0000256|ARBA:ARBA00024227};
GN ORFNames=CBC21_07080 {ECO:0000313|EMBL:OUU57090.1};
OS Proteobacteria bacterium TMED61.
OC Bacteria; Pseudomonadota.
OX NCBI_TaxID=1986601 {ECO:0000313|EMBL:OUU57090.1, ECO:0000313|Proteomes:UP000196561};
RN [1] {ECO:0000313|EMBL:OUU57090.1, ECO:0000313|Proteomes:UP000196561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED61 {ECO:0000313|EMBL:OUU57090.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) +
CC N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:11756, Rhea:RHEA-
CC COMP:9752, Rhea:RHEA-COMP:10505, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29969, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:57586, ChEBI:CHEBI:83144, ChEBI:CHEBI:456215;
CC EC=6.3.4.15; Evidence={ECO:0000256|ARBA:ARBA00000933};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUU57090.1}.
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DR EMBL; NHDO01000045; OUU57090.1; -; Genomic_DNA.
DR Proteomes; UP000196561; Unassembled WGS sequence.
DR GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd16442; BPL; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR InterPro; IPR003142; BPL_C.
DR InterPro; IPR004143; BPL_LPL_catalytic.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00121; birA_ligase; 1.
DR PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR Pfam; PF02237; BPL_C; 1.
DR Pfam; PF03099; BPL_LplA_LipB; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE 4: Predicted;
KW Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OUU57090.1}.
FT DOMAIN 80..262
FT /note="BPL/LPL catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51733"
SQ SEQUENCE 329 AA; 35699 MW; 4F5F3228810F9784 CRC64;
MTADRTRLVR MLPTDRSLSL GELANATQID EATVAELLQQ LEQDGLPLHK ESDTHYRLLE
PVLPIDVSDL VEQLENTGFA FARQAVVLDT VDSTSDWLSR EQQAGRDIHG KACITEFQSA
GRGRRGRSWQ GSPYCHLMLS IGWRFQKEAA EMTGLSLSIG VAVAECLKEL AGVPVGLKWP
NDLWYRDQKX GGILVDLNAS SGGATVAVVG IGINLHEPDS NQFDPGQPXT DLFSNAEGDL
PPRTTIIGHV LGAIANVLDR FXQHQFAPDQ XRFNALDVFA GRXVRTESKG KRLEGVGAGA
DELGRYCVHC ADGVVETINS GDISLSLAD
//
