ID A0A1Z8VI37_9PROT Unreviewed; 673 AA.
AC A0A1Z8VI37;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Methylmalonyl-CoA mutase {ECO:0000313|EMBL:OUU58855.1};
DE Flags: Fragment;
GN ORFNames=CBC21_03730 {ECO:0000313|EMBL:OUU58855.1};
OS Proteobacteria bacterium TMED61.
OC Bacteria; Pseudomonadota.
OX NCBI_TaxID=1986601 {ECO:0000313|EMBL:OUU58855.1, ECO:0000313|Proteomes:UP000196561};
RN [1] {ECO:0000313|EMBL:OUU58855.1, ECO:0000313|Proteomes:UP000196561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED61 {ECO:0000313|EMBL:OUU58855.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUU58855.1}.
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DR EMBL; NHDO01000026; OUU58855.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z8VI37; -.
DR Proteomes; UP000196561; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR PANTHER; PTHR43087:SF1; LAO_AO TRANSPORT SYSTEM ATPASE; 1.
DR PANTHER; PTHR43087; LYSINE/ARGININE/ORNITHINE TRANSPORT SYSTEM KINASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF03308; MeaB; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
PE 4: Predicted;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 22..160
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT REGION 521..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 673
FT /evidence="ECO:0000313|EMBL:OUU58855.1"
SQ SEQUENCE 673 AA; 73445 MW; 8DECCDA26B426514 CRC64;
MSSIPSSLNS LGIPTQPDTA YRVRFVTAAS LFDGHDAAIN IIRRLLQASG AEVIHLGHNR
SVAEIVDAAV QEDVQGIAVS SYQGGHTEFF SYMIDMLRER NRPDIRVFGG GGGVIVEEEI
DALHNYGVSR IYSPGDGQHL GLQGMIDDML ERADFYPAEQ PSESIEGLND PDNVRLARVL
TEIENGTISE FLIRQIRATV TRSKEYTPVL GITGTGGSGK SSLTDEFILR LRIDYGDALR
IAVLAVDPTR RKTGGALLGD RIRMNAIDGD RVFFRSFATR GASAEVPAQL DDLIAACRCA
EFDVVIVETP GIGQGDAGIT SKVDTSLYVM TPEFGAASQL EKIEMLDYAD AVAINKSDRK
GAKDALRDVR KQVQRNRGAF SQSSDEMPVY TTMAARFNDA GVSELYQALK VSLVAQGLIP
GPGLLDETRS ARQSAQSLPG ERERYLAEVA DSVRRYHERV DELETLARRR QHLRTSIDLL
KSGGQSTEPL EVLAGEAETA LGKDVLSQIE GFDGLRAQYR EEDPNGEYRD SKKTQSASYT
SLSGTRIPRV SLPRYHDAGD RLRWQLLENV PGSFPFTAGV FPFKRENEDP TRMFAGEGDA
ARTNQRFRLL SADSSAKRLS TAFDSVTLYG ADPAVRPDIY GKVGTSGVSI ATLDDMKTLY
GGFDLCDPAT SVS
//
