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Database: UniProt
Entry: A0A1Z9D3U2_9ACTO
LinkDB: A0A1Z9D3U2_9ACTO
Original site: A0A1Z9D3U2_9ACTO 
ID   A0A1Z9D3U2_9ACTO        Unreviewed;       339 AA.
AC   A0A1Z9D3U2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=CBC75_06545 {ECO:0000313|EMBL:OUV51893.1};
OS   Actinomycetales bacterium TMED115.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales.
OX   NCBI_TaxID=1986615 {ECO:0000313|EMBL:OUV51893.1, ECO:0000313|Proteomes:UP000196314};
RN   [1] {ECO:0000313|EMBL:OUV51893.1, ECO:0000313|Proteomes:UP000196314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMED115 {ECO:0000313|EMBL:OUV51893.1};
RA   Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT   "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT   for marine microbiology.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUV51893.1}.
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DR   EMBL; NHFQ01000015; OUV51893.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Z9D3U2; -.
DR   Proteomes; UP000196314; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          16..62
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000259|Pfam:PF08220"
FT   DOMAIN          103..322
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   339 AA;  37055 MW;  3C426C544728E28C CRC64;
     MLEDRRLAVL SAIVEDYVAT HEPVGSKALV ERHHLGVSPA TIRNDMAALE EEGYITHPHT
     SAGRIPTDHG YRLFVDQISN VKPMSAPERK AIERFLQDAV DLDDVMGRTV RLLAQITQQV
     ALVQYPSLER SSVRHVELIA VSDTRLMLVV IMDTGRVEQR VIECAAPLSE QLLGDLRARL
     NAAVADKPFA FVSDAMKDLD EGFDAGDKRL VQAVMAAVLE AVTERIEERV VLGGTAHLAR
     YQQSFPMAIQ PVLEALEEQV VLLRLLGELS IESPVTVRIG EENDVHGLES TSVVTAGYGR
     SDQPVASLGI VGPTHMDYVG TMSAVHAVAQ YVSKILKGQ
//
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