ID A0A1Z9D3U2_9ACTO Unreviewed; 339 AA.
AC A0A1Z9D3U2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=CBC75_06545 {ECO:0000313|EMBL:OUV51893.1};
OS Actinomycetales bacterium TMED115.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales.
OX NCBI_TaxID=1986615 {ECO:0000313|EMBL:OUV51893.1, ECO:0000313|Proteomes:UP000196314};
RN [1] {ECO:0000313|EMBL:OUV51893.1, ECO:0000313|Proteomes:UP000196314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED115 {ECO:0000313|EMBL:OUV51893.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUV51893.1}.
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DR EMBL; NHFQ01000015; OUV51893.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z9D3U2; -.
DR Proteomes; UP000196314; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF08220; HTH_DeoR; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 16..62
FT /note="HTH deoR-type"
FT /evidence="ECO:0000259|Pfam:PF08220"
FT DOMAIN 103..322
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 339 AA; 37055 MW; 3C426C544728E28C CRC64;
MLEDRRLAVL SAIVEDYVAT HEPVGSKALV ERHHLGVSPA TIRNDMAALE EEGYITHPHT
SAGRIPTDHG YRLFVDQISN VKPMSAPERK AIERFLQDAV DLDDVMGRTV RLLAQITQQV
ALVQYPSLER SSVRHVELIA VSDTRLMLVV IMDTGRVEQR VIECAAPLSE QLLGDLRARL
NAAVADKPFA FVSDAMKDLD EGFDAGDKRL VQAVMAAVLE AVTERIEERV VLGGTAHLAR
YQQSFPMAIQ PVLEALEEQV VLLRLLGELS IESPVTVRIG EENDVHGLES TSVVTAGYGR
SDQPVASLGI VGPTHMDYVG TMSAVHAVAQ YVSKILKGQ
//