ID   A0A1Z9FBF3_9RICK        Unreviewed;       624 AA.
AC   A0A1Z9FBF3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Propionyl-CoA synthetase {ECO:0000313|EMBL:OUV79046.1};
GN   Name=prpE {ECO:0000313|EMBL:OUV79046.1};
GN   ORFNames=CBC91_04165 {ECO:0000313|EMBL:OUV79046.1};
OS   Rickettsiales bacterium TMED131.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales.
OX   NCBI_TaxID=1986867 {ECO:0000313|EMBL:OUV79046.1, ECO:0000313|Proteomes:UP000196340};
RN   [1] {ECO:0000313|EMBL:OUV79046.1, ECO:0000313|Proteomes:UP000196340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMED131 {ECO:0000313|EMBL:OUV79046.1};
RA   Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT   "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT   for marine microbiology.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUV79046.1}.
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DR   EMBL; NHGG01000059; OUV79046.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Z9FBF3; -.
DR   Proteomes; UP000196340; Unassembled WGS sequence.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990}.
FT   DOMAIN          3..56
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          63..444
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          509..587
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   624 AA;  69739 MW;  313F13E5A93F4604 CRC64;
     MSYEKNYLAW QKNPLSFWKE KSKAISWIEP FTKTLHTENN KSTWFYEGKL NTCYNCIDRH
     VENGHGEKVS LIYDSPITNT KRKINYKELL SKVSSLAASL SKLGVRKGDT VIIYMPMIPE
     VIFSMLACAR IGAIHSVVFG GFASKELASR ISDVTPKVIV SASCGLEPNK IINYKKILDE
     ALTFTSHKPL KKVIYQREQY LCNLDQPTDI SWDDFIDCSS RIDCIPVDSN DPLYILHTSG
     TTGVPKGIVR TNGGHAVALY NSMKMTYDIT ENDVFWAASD VGWVVGHSYI VYAPLLLGCS
     TVLYEGKPVG TPDSGQFWRV ISEHKVKTMF TAPTAIRAIK KEDAQGQQVK KYNLSSLKYI
     FLAGERADPE SIKWTMNITK KPVIDHWWQT ETGWSIAGNF PEYELFDILH GSTGKAAVGY
     SVVVLNDKGK ELAREKMGNL AIRLPLPPGC SSQIWNSANR FYEAYLKKYP GYYDTSDAGI
     INNDGYISVM SRTDDIINCA GHRISTGSIE EILTQHEDVA ECAVIGMNDN LKGQVPVGIL
     VLNNSCIKSE DEVVNETIDL VREKLGPVAS YKKSLIVTNL PKTRSGKILR STISNILNKT
     EYKTPATIED INTLELIKKL SNLI
//