ID A0A1Z9LMD4_9CYAN Unreviewed; 685 AA.
AC A0A1Z9LMD4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=CBD48_02325 {ECO:0000313|EMBL:OUW56471.1};
OS Cyanobacteria bacterium TMED188.
OC Bacteria; Cyanobacteriota.
OX NCBI_TaxID=1986678 {ECO:0000313|EMBL:OUW56471.1, ECO:0000313|Proteomes:UP000195725};
RN [1] {ECO:0000313|EMBL:OUW56471.1, ECO:0000313|Proteomes:UP000195725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED188 {ECO:0000313|EMBL:OUW56471.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUW56471.1}.
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DR EMBL; NHIL01000020; OUW56471.1; -; Genomic_DNA.
DR Proteomes; UP000195725; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43711:SF32; DRUG SENSORY PROTEIN A; 1.
DR PANTHER; PTHR43711; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08448; PAS_4; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OUW56471.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 233..285
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 421..663
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 685 AA; 75351 MW; 96592F3CF4D198E1 CRC64;
MSSGSDRAIA DWALPQGEPP RGDAGLWERI TDWWAEFTLQ TKLLAVATLV VSLMMTGITF
FALNGIQRDA VMSDTRYARD LGLLLAGNVT EXVAQGQDRE LANVAEKFWR SSRSVRXIFF
ADPEGVIYLG IPISATPLSS EGELRLNRRL ELPDELQRRP QNPLVRQHLT PQGTITDVFV
PLIRNGEYYG VLGLGVNPND TALASAALTR EVTVAVFISI WVLVILGAVF NALTITRPVK
ELLKGVRSVA SGNFRARVDL PMGGEXGELL TGFNAMASQL EAYDEANIXE LTAAQVKQQS
LIATMADGAI LLDQSGRIVL AXPTARRLFR WEGRSLEGQE LVEELPELLA IEVHTPLXAL
MSGADSEDLR CKVGEPARTL RIVMQAVRDA SGESLKGIAV TIQDLTREVE LNAAXSRFIS
NVSHELRTPL FNIKSYVETL HDLGDQLTEE EQKEFLGVAN DETDRLTRLV NDVLDLSRLE
SGRTIQFEAM NLRPAMEQTL RTYRLNAEDK QVXLMLDVAP DLPDVLGNWD LLLQVFDNLV
GNALKFSRAG GVLAXRAYPW PDTCQVKPTG QVSQAEGPTC VLTSPLPKLR VEIADTGCGI
SXADQERIXD RFXRVENAVH TEVGTGLGLS IVRGILEKHG AQVSMVSELD VGTTFWFDLP
LEQADKDEVQ LQAERRALCE QVTSS
//
