ID   A0A1Z9MUK7_9RICK        Unreviewed;       409 AA.
AC   A0A1Z9MUK7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-NOV-2023, entry version 13.
DE   SubName: Full=4-hydroxytetrahydrobiopterin dehydratase {ECO:0000313|EMBL:OUW71088.1};
GN   ORFNames=CBD71_03045 {ECO:0000313|EMBL:OUW71088.1};
OS   Rickettsiales bacterium TMED211.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales.
OX   NCBI_TaxID=1986869 {ECO:0000313|EMBL:OUW71088.1, ECO:0000313|Proteomes:UP000195710};
RN   [1] {ECO:0000313|EMBL:OUW71088.1, ECO:0000313|Proteomes:UP000195710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMED211 {ECO:0000313|EMBL:OUW71088.1};
RA   Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT   "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT   for marine microbiology.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUW71088.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NHJI01000045; OUW71088.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Z9MUK7; -.
DR   Proteomes; UP000195710; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047920; ZigA-like.
DR   NCBIfam; NF038288; chaper_GTP_ZigA; 1.
DR   PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   PANTHER; PTHR43603:SF1; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          262..379
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
SQ   SEQUENCE   409 AA;  46351 MW;  A9E2542085F9778F CRC64;
     MKVLEKKLPV TVLSGFLGAG KTTLLNHILN NRENLKVAVI VNDMSEVNID ANLVERGGGN
     LSQTEEKLVE MSNGCICCTL REDLLMQVRE LATEDKFDYL LIESTGISEP LPVASTFDFR
     DEDGNSLSDV AQLDTMVTVV DSANLIRNYS STDFLKDKGE SLGEDDERTL VDLLVDQIEF
     ANVILLNKID LISNDELKTV KAIIRGLNVK AKIIETKSSQ VSLNKLMGTS LFNLEEAKDH
     PLWAQELYNF KDHVSETEEY GITSFVYCAR KPFDPSKVYD FFNQEWPGVI RSKGFFWLSS
     RPDFVGEVSQ AGAFVRHQGI GRWWAAVPKN QWPTGEDLTQ VMKKYWNEDI GDRRQEIVFI
     GLKAEMNEQS IRERLDACLI KSYETSPNSN HEISDPFPKW FQKTVQNAK
//