ID A0A1Z9NGU8_9EURY Unreviewed; 755 AA.
AC A0A1Z9NGU8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=CBD75_02410 {ECO:0000313|EMBL:OUW78766.1};
OS Euryarchaeota archaeon TMED215.
OC Archaea; Euryarchaeota.
OX NCBI_TaxID=1986690 {ECO:0000313|EMBL:OUW78766.1, ECO:0000313|Proteomes:UP000195966};
RN [1] {ECO:0000313|EMBL:OUW78766.1, ECO:0000313|Proteomes:UP000195966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED215 {ECO:0000313|EMBL:OUW78766.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUW78766.1}.
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DR EMBL; NHJM01000011; OUW78766.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z9NGU8; -.
DR Proteomes; UP000195966; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR42785:SF1; DNA TOPOISOMERASE; 1.
DR PANTHER; PTHR42785; DNA TOPOISOMERASE, TYPE IA, CORE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..120
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 755 AA; 84757 MW; 37CC2960E3C3B737 CRC64;
MKLMILESGA KGKTVKKYLG KGWIVEACFG HVQDLPRSGS QGNKAMWASE KGKLPEPPWE
WTERSERVVT KLLTKARSKN VSEVYIATDP DREGEFIAWR LMELFSEFPF VTRVTFNEIT
KEAVESALQN HGDIDQGLVD AAKVRRFMDR LVGFRCSKFA KSWNLRSMGR VQTPTLGYIV
DRENERNAHV PIPYHTVHTI SDGYTFKFRF HESKDDDAWR DDNGKFFSDR TFDHELAEEA
FSALSNSRNM KVLNVKDGKT NRKPSPPFTT DTLLQSSSSS LGWSMSKTSK IASDLYNKGF
ITYIRTDSTR TSSGARKIAR EIILEEYGED HLGSGSLGPD AKKNTGNVQD AHEAIRPTDP
RLSEPTDLEN DAIKLYRLIR SRFLSSQMSD SIRERREIIA SVDGTGLQVS GTASWRIHPG
WESASSEFLA KPRIEEPQYA LSEGSIWLID ELDENPNMTT DETKPPRRYT ESSIVKKMKN
AGIGRPSTYV STVLKLSDRK YITNDNGSLT PTDNGMLLWT EVAPIYNDQE SEVDLFSSEF
TSDMEQQLDS VEDGVAAGSE MWLRFSTSFK EAHQKAIEIK GRTPTPRQRY SIENQISGME
DAEKKAIMNG KLISEISGKE AGEIIERLKE MAKEGKIITK PSEKQMSYLM SLIEKSNMTE
EEALALLELG DFNDLTGGRN GSASELIGLM KEVNESLPAS EAQINLITNM SEKLGIPIAD
VLAMADLAEI SEISKSDASK IITNLKSLRK KSRKK
//
