ID A0A1Z9NHU1_9EURY Unreviewed; 326 AA.
AC A0A1Z9NHU1;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Mevalonate kinase {ECO:0000313|EMBL:OUW79365.1};
GN ORFNames=CBD75_00750 {ECO:0000313|EMBL:OUW79365.1};
OS Euryarchaeota archaeon TMED215.
OC Archaea; Euryarchaeota.
OX NCBI_TaxID=1986690 {ECO:0000313|EMBL:OUW79365.1, ECO:0000313|Proteomes:UP000195966};
RN [1] {ECO:0000313|EMBL:OUW79365.1, ECO:0000313|Proteomes:UP000195966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED215 {ECO:0000313|EMBL:OUW79365.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC step 1/3. {ECO:0000256|ARBA:ARBA00029438}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUW79365.1}.
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DR EMBL; NHJM01000004; OUW79365.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z9NHU1; -.
DR UniPathway; UPA00057; UER00098.
DR Proteomes; UP000195966; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004496; F:mevalonate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.890; GHMP kinase, C-terminal domain; 1.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006205; Mev_gal_kin.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00549; mevalon_kin; 1.
DR PANTHER; PTHR43290; MEVALONATE KINASE; 1.
DR PANTHER; PTHR43290:SF2; MEVALONATE KINASE; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|EMBL:OUW79365.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:OUW79365.1}.
FT DOMAIN 75..144
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 232..303
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 326 AA; 33878 MW; 287295D3E759D1DD CRC64;
MARAFAPGKC ILFGEHAVVY GQPAVAVSIE AGVEVSISES NRWSLEGLPF EPSRHPHISH
IINDIFKYSG PPLEIDIKSS LYSAAGLGSS AALSNAMGAA LQELVNPEEN LDLVALARMG
HSAEANAQKG RASPTDTATS ALGGCIVVSG SSVPGTKHIF DSALETPEGS RTWSVGRVEI
PKIEDVWLVL GFTGIGSPTG EMVEGVSELL KSNPLKMAEI EAIGEITSRG LSALSSGKME
EVGLAMNACH HRLRNIGVSS PELENLISAT EGHSLGTKLT GAGGGGCMVS LTRNPQRVAE
CIEIAGGKPL ISKFGSGGAR ILMQEN
//