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Database: UniProt
Entry: A0A1Z9NI21_9EURY
LinkDB: A0A1Z9NI21_9EURY
Original site: A0A1Z9NI21_9EURY 
ID   A0A1Z9NI21_9EURY        Unreviewed;       448 AA.
AC   A0A1Z9NI21;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   08-MAY-2019, entry version 7.
DE   RecName: Full=Probable thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=CBD75_01005 {ECO:0000313|EMBL:OUW79412.1};
OS   Euryarchaeota archaeon TMED215.
OC   Archaea; Euryarchaeota.
OX   NCBI_TaxID=1986690 {ECO:0000313|EMBL:OUW79412.1};
RN   [1] {ECO:0000313|EMBL:OUW79412.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMED215 {ECO:0000313|EMBL:OUW79412.1};
RA   Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT   "290 Metagenome-assembled Genomes from the Mediterranean Sea: a
RT   resource for marine microbiology.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00165}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OUW79412.1}.
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DR   EMBL; NHJM01000004; OUW79412.1; -; Genomic_DNA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000313|EMBL:OUW79412.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165}.
FT   DOMAIN        6    174       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
SQ   SEQUENCE   448 AA;  50093 MW;  EC6A16FD1D725452 CRC64;
     MYLITIEGGD GSGKGLATKV VSEVMRKEFP FVSVSVTGEP RRDHPLGRLA IDSVRKKTTS
     PEREAGLFAA DRVDHSHGWI LPRLESGIGV VSERNIHSSL VYQGIVGKLG IERVAHMNSA
     ALVPDLCIWV DCDPSVALDR IKSGTLRAHS DKEEYFETSE LQIMIRQGYR ELLSGNIEMP
     TPFDMGAIIG PVLNEGSEDD FKMKLKSLIR NFMHSRPEPV NVLSEVVDRN LVSELIISSR
     GQSTLQGLGV KPAIGEQEWL DGNSPWRVLK NFQKSHSXVL GELLEGERSD VPKRVLSHSF
     SSICGTLSLM RTANIRELRK SLGPVRSVSE RHTQTIVRYL NEKLGCIHQH RALIGREAPR
     SQMNDESRXF GRLAIAIWPL RDIIMKWMKK NPDTHIRFAM GQIIRSGKYP SAAKSTLERI
     AILGPGRGSF PLPKDEDDLI SWWTMKSI
//
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