ID A0A1Z9NIB9_9EURY Unreviewed; 377 AA.
AC A0A1Z9NIB9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Semialdehyde dehydrogenase NAD-binding domain-containing protein {ECO:0000259|SMART:SM00859};
GN ORFNames=CBD75_01085 {ECO:0000313|EMBL:OUW79428.1};
OS Euryarchaeota archaeon TMED215.
OC Archaea; Euryarchaeota.
OX NCBI_TaxID=1986690 {ECO:0000313|EMBL:OUW79428.1, ECO:0000313|Proteomes:UP000195966};
RN [1] {ECO:0000313|EMBL:OUW79428.1, ECO:0000313|Proteomes:UP000195966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED215 {ECO:0000313|EMBL:OUW79428.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUW79428.1}.
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DR EMBL; NHJM01000004; OUW79428.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z9NIB9; -.
DR Proteomes; UP000195966; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 8..139
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 156
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 249
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 377 AA; 41232 MW; BE73DB1E110E71CF CRC64;
MEVLGRVKCA ILGARGLVAQ RLLQRLVNHH WLIPTHVFGS KESDGIGVNE IPWSFNEPRP
DFPDIIVRAM GESNELASEL ISQGVRIVFS ALPDSPASMI EEDLARSGLV VLSHSTIHRH
SEIVPLIVPE VNPEHLDLLE TQNEFGSGAL VSCSNCMVVP LAVSLAPIVR KFPVNSISIS
TEQSVSGAGR RVLERYREGV MPGPEIIGES QSIESELRRI LNEYDSSESD SANLKINAQC
KRFPREFGHS ATVTVDLGRD VSAHEVIEAW SDFHSLVQHL DLPSGTKKPL IFDSETGPST
TSLNYKKSNK LDIDMQKSMD VLVGDINISG SKLCYRVASD NTVRGAAGNS ILLAEMMLAQ
GIIHDSKNIL KSSQNVR
//
