ID A0A1Z9T6U6_9BACT Unreviewed; 745 AA.
AC A0A1Z9T6U6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=CBE26_04685 {ECO:0000313|EMBL:OUX36686.1};
OS Kiritimatiellaceae bacterium TMED266.
OC Bacteria; Kiritimatiellota; Kiritimatiellia; Kiritimatiellales;
OC Kiritimatiellaceae.
OX NCBI_TaxID=1987167 {ECO:0000313|EMBL:OUX36686.1, ECO:0000313|Proteomes:UP000198223};
RN [1] {ECO:0000313|EMBL:OUX36686.1, ECO:0000313|Proteomes:UP000198223}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED266 {ECO:0000313|EMBL:OUX36686.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUX36686.1}.
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DR EMBL; NHLL01000027; OUX36686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z9T6U6; -.
DR Proteomes; UP000198223; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF00773; RNB; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 627..708
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 707..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 588..615
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 710..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 84947 MW; 6A72F63C71DB5BC5 CRC64;
MSIDNQIIDF MKQPDYLPMK QHELAQALGI EDKEKRRSMR HQLYELEDRG TIVRLRKNRW
SLPNRENRMT GVVKMLPKGG AVIISDDPDV EEVFVGARNL GLAFPNDIVE VERYHSAYGE
RSDSSKANGR RSEGRVTGVI ERRMLEMVGT LKKARYHYFV TADDPNFPHS VRVSDCEHIE
KNHKVLVRLD PWTDPYQAIT GIIVDDLGEA SAPGVDVDSM LRGAGIEEAF PDRVIAEAEA
IPKEIPLSMM EGRRDLRKEV IFTIDPDTAR DFDDAISLEP HPDGGWQLGV HIADVSAYVK
PGSALDTEGY KRGNSIYLVD RVVMMLPTEL TTQICSLNPN EDHLTHSAYI HLSDNGERLG
YETFPAVIHS QCRMTYKQVQ KHIDGEEGHQ IPTFIQERLN NLYPLIRKVR RNRIQQGSLE
INTPDVEIKL NERGEVESMI PRSAAKEAYQ LIEDCMLLAN RAVAEKLMEA DRPALYRIHE
EPDEEQWNKM AMELNALGIP VLPRSRKELN EAFALAEGTP TEYTALLAIL RNFKRAEYAA
RQVGHFGLAF EDYTHFTSPI RRYPDLVVHR LLKSIEKNSP PKLSKENIEE IAAHCTETEK
KADELEKKST EKKRLDYYNG LLKAGKNSTF NGFIVGIKKR GMVIELPDSL QRGMVAFASI
RSEWLEADDT LTEVANREGT TRYRLGDPLE VMIAKVDTER ALLDFMIPGE PQKRTRHGRK
PRIEPDLRSG KAKSPTKKGR RRRKR
//
