ID A0A1Z9U2N6_9EURY Unreviewed; 265 AA.
AC A0A1Z9U2N6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=CBE39_02910 {ECO:0000313|EMBL:OUX47490.1};
OS Euryarchaeota archaeon TMED279.
OC Archaea; Euryarchaeota.
OX NCBI_TaxID=1986694 {ECO:0000313|EMBL:OUX47490.1, ECO:0000313|Proteomes:UP000196083};
RN [1] {ECO:0000313|EMBL:OUX47490.1, ECO:0000313|Proteomes:UP000196083}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMED279 {ECO:0000313|EMBL:OUX47490.1};
RA Tully B.J., Sachdeva R., Graham E.D., Heidelberg J.F.;
RT "290 Metagenome-assembled Genomes from the Mediterranean Sea: a resource
RT for marine microbiology.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUX47490.1}.
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DR EMBL; NHLY01000031; OUX47490.1; -; Genomic_DNA.
DR Proteomes; UP000196083; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 2.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..265
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 265 AA; 29997 MW; 846ED3D49D7913AA CRC64;
MQEYLDLMQR ILDXGEEKGD RTGTGTLSVF GHQMRFDLSK GFPMVTTKKL HLXSIVHELL
WFLAGDTNXA XLQXXGVXXW XXWADENGDX GPVYGKQWRK WXSKDGKVID QIEQAIDMIK
NNPNSRRIIV SAWNVGELED MALMPCHAFF QFHVAGGKLN CQLYQRSADV FLGVPFNIAS
YALLTHMMAQ VCDLEAGTFV HTIGDAHLYT NHLEQTELQL SRTPIXPLPT LKLNPDIKNI
DDFTYEDIEV VGYEHXPHIK APIAV
//
