ID A0A200PP85_9MAGN Unreviewed; 367 AA.
AC A0A200PP85;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=O-methyltransferase {ECO:0000313|EMBL:OVA00009.1};
GN ORFNames=BVC80_8595g16 {ECO:0000313|EMBL:OVA00009.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA00009.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA00009.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA00009.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA00009.1}.
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DR EMBL; MVGT01004385; OVA00009.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A200PP85; -.
DR STRING; 56857.A0A200PP85; -.
DR InParanoid; A0A200PP85; -.
DR OrthoDB; 5230501at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR012967; Plant_MeTrfase_dimerisation.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF08100; Dimerisation; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Alkaloid metabolism {ECO:0000256|ARBA:ARBA00022589};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OVA00009.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OVA00009.1}.
FT DOMAIN 32..79
FT /note="Plant methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF08100"
FT DOMAIN 138..348
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 272
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 367 AA; 41144 MW; 4073B7F118EAF5FE CRC64;
MDSSASTEVK GNELLQVHAH VWKYAFSYIS SMCLKCAVQL SIPEIIHNHG KPMTLSSLVD
ALSLPPSKTE AVNRLMRFLI HAGFFATQKL DENQEDLEEV AEEGFLLTPS SRYLIKDDTN
TLSSIVLAIV DPVLVTPFYS LSDWFRGNGS TTFEAGQGMG IWNFLEHHPE YSKNFNYAMA
NDSRPIMSVV VNEGKAVFEN LKSLVDVGGG NGTSAKAIAE AFPHLKCLVL DLPHVVADHI
PKINTKNLDF IGGNMFDSIP RADAVLMKNI LHDWSDKDCV KILKRCREAI PGREEGGKMI
ILDVVMEDRK QEHDSTEIQL LFDMIMMTIG GKERTEKEWK KLFLESGFTD YKITPLLGFR
SIIEVYP
//
