ID A0A200PWY2_9MAGN Unreviewed; 745 AA.
AC A0A200PWY2;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Histidine triad (HIT) protein {ECO:0000313|EMBL:OVA02743.1};
GN ORFNames=BVC80_9093g88 {ECO:0000313|EMBL:OVA02743.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA02743.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA02743.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA02743.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00464}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA02743.1}.
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DR EMBL; MVGT01003948; OVA02743.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A200PWY2; -.
DR STRING; 56857.A0A200PWY2; -.
DR InParanoid; A0A200PWY2; -.
DR OrthoDB; 12181at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0047627; F:adenylylsulfatase activity; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:UniProt.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR019808; Histidine_triad_CS.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032566; Znf-C2HE.
DR PANTHER; PTHR12486:SF4; APRATAXIN; 1.
DR PANTHER; PTHR12486; APRATAXIN-RELATED; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF11969; DcpS_C; 1.
DR Pfam; PF01661; Macro; 1.
DR Pfam; PF16278; zf-C2HE; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR PROSITE; PS00892; HIT_1; 1.
DR PROSITE; PS51084; HIT_2; 1.
DR PROSITE; PS51154; MACRO; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 314..556
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 547..655
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT REGION 201..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 81827 MW; 63C0C67C033B0D23 CRC64;
MSLTTQVQAV TIHATHNYFV TASLDNTWCF YDLSSGLCLT QDTIGNGKAG TKAQCLKSAT
DALKDGKSVF IDRCNLEREQ RSDFVKLGGS NVDVHAVVLD LPARLCISRS IKRTGHEGNL
QGGKAAAVVN RMLQKKELPK LNEGFSRITF CLNERDVEEA VKTYSALGPL DTLPSGCFGQ
KNPDAKVQLG IMKFLKKVEA PDNSSKDPVS KKESKESDTS CKERETVTSS VGNTDEKVKE
DEDLRKDSST GATSLNDVPT LAFPSISTSD FQFNHEKASD IIVEKVEEFL NKVGNARLVL
VDLTAGSRIL TSVKVKAAQR SIDSNKFFTL VGDITQLYTK GGLRCNVIAN VANWRLKPGG
GGVNAAIFSA AGPDLEIATK KQAGSLSPGS ALTVPLPSNS PLYKKEGVTH VIHVLGPNMN
PQRPNYLNND YDKGCTVLRE AYSSLFEGFA SIVRTQTTES SKNLFRSSTD HSPTSDQKGK
REGVYESDSN KKCKGLQGEV GVQQISESNE KGIQSDSTRA TGIRTQLKKD ETDGGTTKAW
GSWAQSLYRT AMHPENHKND VIEISDDVVV LNDLYPKAQK HLLILARKDG LDRLADVREE
HLPLLRTMHA VGVKWAKKLL SDETSLVFRL GYHSAPSMRQ LHLHVISQDF NSTHLKNKKH
WNSFNTIFFR DSVDVIEEIG NHGKAKLNDE DSLMSMELRC HRCRSAHPNI PRLKSHISNC
RAPFPSTLLQ NERLIIASSG AGSEA
//
