ID A0A200Q0W5_9MAGN Unreviewed; 2097 AA.
AC A0A200Q0W5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BVC80_8671g3 {ECO:0000313|EMBL:OVA04103.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA04103.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA04103.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA04103.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA04103.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MVGT01003398; OVA04103.1; -; Genomic_DNA.
DR STRING; 56857.A0A200Q0W5; -.
DR InParanoid; A0A200Q0W5; -.
DR OrthoDB; 501776at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0048544; P:recognition of pollen; IEA:InterPro.
DR CDD; cd00028; B_lectin; 2.
DR CDD; cd01098; PAN_AP_plant; 2.
DR CDD; cd14066; STKc_IRAK; 3.
DR Gene3D; 2.90.10.10; Bulb-type lectin domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 3.
DR InterPro; IPR001480; Bulb-type_lectin_dom.
DR InterPro; IPR036426; Bulb-type_lectin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR021820; S-locus_recpt_kinase_C.
DR InterPro; IPR000858; S_locus_glycoprot_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR32444; BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR32444:SF158; RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF01453; B_lectin; 3.
DR Pfam; PF11883; DUF3403; 2.
DR Pfam; PF08276; PAN_2; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 3.
DR Pfam; PF00954; S_locus_glycop; 3.
DR SMART; SM00108; B_lectin; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00473; PAN_AP; 2.
DR SMART; SM00220; S_TKc; 3.
DR SUPFAM; SSF51110; alpha-D-mannose-specific plant lectins; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 3.
DR PROSITE; PS50927; BULB_LECTIN; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50948; PAN; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 3.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Kinase {ECO:0000313|EMBL:OVA04103.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1696..1721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..148
FT /note="Bulb-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50927"
FT DOMAIN 341..415
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 496..776
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 929..965
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 994..1274
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1309..1429
FT /note="Bulb-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50927"
FT DOMAIN 1623..1698
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 1777..2057
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1732..1753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2097 AA; 235473 MW; B81AEF2F2B5DF1AE CRC64;
MEDLPFFIFC YTFTVSVLLD ISFAVDAITQ NHSISDVGRQ TLVSSGGSFE LGFFSPGSSK
SRYLGLWYKN IPSPVVWVAN RNNPITDSSG VLKIGSDGNI VLVNGTENVV WSSNSSIPTL
VNPIALLLDS GNLVLRDERS SNSDTHIWQS FDYPCDTLLP GMKHGWSLKE NKNWSLSSWK
SIDDPSPGDF IYSVDHVGLP QFVLRKGSEI QFRSGNYDGA RFGGDPEIKI TPVFKPKFVF
NPNEVYYTFE DIYPTITRFV LNQSGSIDHL KWNDESREWI PLITLHRDNC DNYAACGANA
ACNINDTPMC HCLKGFTPKS PQESIAFDLS AGCIRSSPLN CSKGEGFEKF TRMKLPDKSE
VLNTSNRCDR ECLARCSCTA YAVTAVTSCA VWFGDLVDIR EYIKGGATDL YIRMAANELD
SNSKKMKIII VSVVLGTFLL GSISWFIIWK KRRANRGVAG IHISNQDRDY TDKSQEEDLE
LHIFDFATIA AATNNFSFAN KIGEGGFGPV YKGQLSTGQE IAVKTLAKDS GQGINEFKNE
VMLIAKLQHR NLVRILGCCI QGEDRMLIYE YMPNKSLDTF IFDKTRGISL NWRERFDIIV
GIARGLLYLH QDSRLRIVHR DLKASNILLD GNMNPKISDF GAAKTFIGDQ TEANTKRVVG
TYGYMSPEYA IDGLFSMKSD VFSYGVIVLE IVSGKKNRGF YHPDHDLNLL GHVWKLWNEG
KALELMDEKM ETPVPLPMSE VLRCIHVGLL CVQQRPVDRP TMSSVVLMLG SDTATLPQPK
QPGFSTESYL WQSFDYPCDT LLPGMKLGWS SKETRNWSLS SWKNADDPSP GDFTYGIDPG
GLPQIVLRKG SKIQFRSGNY DGVQFGGEPE LKITRAFKPI FIFKRDEVYY TFEDINPAIT
RFVLSPTGSP DHFKWNDGSR VWVTIFTSHR DNCDTYAACG AHGICNIIDS RMCKCLKGFT
PKSPQEDYTD EGQEEDLELH IFGFATIEAA TNNFAFANKI GEGGFGPVYK GQLSMGQEIA
VKRLAKDSGQ GITAFKSEVM LIAKLQHRNL VRLLGCCIQG EERMLIYEYM PNKSLDAFIF
DKRKDISLNW RKRFDIIVGI ARGLLYLHQD SRLRIIHRDL KASNILLDSD MNPKISDFGA
AKTFRGDQTE ANTKRVVGTY GYMSPEYAID GLFSMKSDIF SFGVVVLEIV SGKKNRGFYH
PDHDLNLLGH VWKLWNEGKA LELMDAKMET PFPLPMSEVL RCIHVGLLCV QQRPEDRPTM
SSVVLMLASD TATLPKPKQP GFSTERFLTD LESSSCDTGN ELTVTAFEVD TIAPDQSIRG
NQTLVSAGGS FELGFFTPGN SRNQYLGMWF KVMPSTVVWV ANRNEPITDS SGVLKISTDG
NIVLLNGTED VVWSSNSSRR VVNPVAQLLE TGNLVLRDES SSNSDSYTWQ SFDYPCDTLL
PGMKIGWSLK AVRNWSLSSW KNSDDPSPGD FTYSVDPRGL PQLVLRKGSE IQFRSGPWDD
GTRFGEDAER QNSIFKPMVV FNKDEVYYIF ENKQKSTISR FLVNQSGTIQ HFRWNDVRHE
WVPMITLHRD NCDNYAACGA YGACNIIESP NCKCLKGFTP KSPQEWNVND PSAGCIRRST
LGCKKGEGFV KFTRVKLPDK SQILNTSTEC ERECLTRCSC MAYAKIDVIS NCAVWLGDDL
IDIREYSEDS SDKKKLVLTI TLVSVVFVIF LLGSISWFII WKKRTAKGEG KKINNQDRDY
HSQEINQERD HTDESREEDL ELHIFEFLTI AAATNNFSFA NKIGEGGFGP VYKGQLLMGQ
EIAVKRLAKD SGQGINEFKN EVMLIAKLQH RNLVRLLGCC IQGEERMLIY EYMPNKSLDT
FIFDKTRGIS LNWGKRLDII MGIARGVLYL HQDSRLRIVH RDLKASNILL DGDMNPKISD
FGAAKTFIGD QTEANTKRVV GTYGYMSPEY AIDGLFSIKS DVFSFGVLVL EIVSGKKNRG
FYHPDHDLNL LGHVWKLWNE GKASELMDEN METPVPLPLS EVLRCIHVGL LCVQQRPENR
PTMSSVVLML GSDTATLPQP KQPGFSTERF LIDNESSSSE KKLYTGNEIT LTTLEGR
//
