ID A0A200QAU5_9MAGN Unreviewed; 378 AA.
AC A0A200QAU5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase {ECO:0000313|EMBL:OVA07581.1};
GN ORFNames=BVC80_8965g9 {ECO:0000313|EMBL:OVA07581.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA07581.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA07581.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA07581.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|RuleBase:RU004475}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA07581.1}.
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DR EMBL; MVGT01002455; OVA07581.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A200QAU5; -.
DR STRING; 56857.A0A200QAU5; -.
DR InParanoid; A0A200QAU5; -.
DR OrthoDB; 1215685at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd08958; FR_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF483; CINNAMOYL COA REDUCTASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:OVA07581.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000195402}.
FT DOMAIN 60..312
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 378 AA; 41410 MW; 7584CCF9246F4470 CRC64;
MGILRTTDSL RADLEEFSRL FLGCAPPAYS KPKFSNLVQE EVVNFREGSE EEEEDKLVCV
TSGASFLGLA IVNRLLNCGY SVRILIENQE DLEKLEQTER FVGGGGGSTI IGNHYSNNNR
RIGGATAEVV MAKVAEVESL CEAFRGCRGV FHTSAFADPA GISGYSKCMA ELEVKASQNV
MDACARTASV RKCVFTSSLL ACVWRNNVLD DLPPLLDHSC WSEESVCREK KLWLALGKTM
AEKAAWRVAE DHEIKLATIC PGFITGPEFC RRNPTSSIAY LKGAQEMYAE GLLATADVSK
VAEAHVCVYE AMSNTGCGRY ICFDHVIQRE EDVLELAGQM GIPANRITSN APSNDSVPRF
QLSNGKLSRL MSRLSRCS
//
