ID   A0A200QBW2_9MAGN        Unreviewed;       740 AA.
AC   A0A200QBW2;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=BVC80_8731g17 {ECO:0000313|EMBL:OVA07958.1};
OS   Macleaya cordata.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC   Macleaya.
OX   NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA07958.1, ECO:0000313|Proteomes:UP000195402};
RN   [1] {ECO:0000313|EMBL:OVA07958.1, ECO:0000313|Proteomes:UP000195402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC   TISSUE=Root {ECO:0000313|EMBL:OVA07958.1};
RX   PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA   Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA   Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA   Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA   Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT   "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT   Benzylisoquinoline Alkaloids Metabolism.";
RL   Mol. Plant 10:975-989(2017).
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OVA07958.1}.
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DR   EMBL; MVGT01002392; OVA07958.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A200QBW2; -.
DR   STRING; 56857.A0A200QBW2; -.
DR   InParanoid; A0A200QBW2; -.
DR   OrthoDB; 608at2759; -.
DR   Proteomes; UP000195402; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016871; F:cycloartenol synthase activity; IEA:UniProt.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 3.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000313|EMBL:OVA07958.1}.
FT   DOMAIN          78..337
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          391..732
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   740 AA;  83358 MW;  995AF7EF59A5C6F6 CRC64;
     MGSIYSEISS QQKFVVKGCG GESSTATLDV QNKKTVQIPW CSLTFAKVNP CGNDLPQVKV
     TDTEDVTEEA VTTTLRRAIT FHSTIQANDG HWPGDYGGPM FLMPGLVITL YITGALNAVL
     SSEHQREMCR YIYNHQNTDG GWGLHIAGPS TMFGTTLNYV SLRLLGEGVD DGEGSIEKGR
     MWILNHGGAT SISSWGKMWL SVLGVFEWSG NNPMPPEIWL LPYLLPVHPG RMWCHCRMVY
     LPMSYLYGKR FVGPITPLIL SLRQELFTVP YDKVDWNKAR SMCAKEDLYY PHSLVQDILW
     ASLHKVIEPI LTCWPANKLR EKALLTTIQH IHHEDEKTRY ICLGPVNKVL NMLCCWVEDP
     NSKEFKLHLP RIYDYLWIAE DGMKMQGYNG SQLWDTAFAI QAIISTNLYE EYGPTLKKAH
     GYIKDSQILE DCVGDLDFYY HRISKGAWTL STADHGWPIS DCTAEGLKAA LLLSKIQPRT
     AFGEPIDAKR LYDAVNVILS LQVNGDDGGF TTYKPSRSYA WLELLNPSET FGDIVIDYPY
     VECTSAAIQA LTSFKKLYPV YRSKDIQHCI AKAVKFIEKI QAPDGSWYGC WGVCFTYGIW
     FGITGLMASG KTFKNSSAIR KACEFLLSKQ LASGGWGESY LSCQNKVYTN LESNQSHLVN
     TAWAMLALID AGQQVERDPS PLHRAARVLI NSQMENGDFP QESIMGVFNK NCMINYAAYR
     NIFPIWALGE YRCRVLQQAR
//