ID A0A200QL29_9MAGN Unreviewed; 532 AA.
AC A0A200QL29;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=BVC80_1741g140 {ECO:0000313|EMBL:OVA11139.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA11139.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA11139.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA11139.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA11139.1}.
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DR EMBL; MVGT01001732; OVA11139.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A200QL29; -.
DR STRING; 56857.A0A200QL29; -.
DR InParanoid; A0A200QL29; -.
DR OrthoDB; 5480520at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254:SF424; E3 UBIQUITIN-PROTEIN LIGASE UPL5; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 188..447
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
SQ SEQUENCE 532 AA; 61298 MW; 0012CC3E1A9ECF2E CRC64;
MMIPRDNMKK SMEHLQIFKF YGAPEALVPL FESPIEGNKE IEATDFIKDL YPFFFELSSK
LLEGLVLIKS QLPCARAIED HVRSKCHSLP LNVEADNFKE HPCYGIEIES LHRDVFFTLL
LGLNSCLYGM RRDIGDGEGA EEEFSSDIQA YPVPIGTLIA YSKRSDDNLW LLKHKGLTES
FKHIANANPK SLRNGLLIEF KYEVATGRSI LREWLCLICQ ELFNPQNSLF LACPNDRRRF
FPYPANDVDP RHLTYFRLCG RVIALALMHN IQVGIAFDRM FFLQLAGEVI SLEDVRYADP
CMYILEMDVD FMDSDAMGLT FVNEIEEFGS RKIVELCPGG NTIIVNSKNR EKYVDLLIQH
CFVKSISKKV AHFARGFGDI LYKRRQQKIF FQSFELEDLD RMLLGSDKTI CVKDWKAHTD
YDDYKETDDQ ICWFWKVVEG MSSEQQKGAT LLLDLGEVPS GKWFFWFAIS FVHLQDIRLS
LSPALSPHML LPLGTPTLPI SSRHAAASPF YMPKTCWLQL RVFVKHSMLC FF
//
