ID A0A200R2P2_9MAGN Unreviewed; 3049 AA.
AC A0A200R2P2;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BVC80_9043g40 {ECO:0000313|EMBL:OVA16997.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA16997.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA16997.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA16997.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA16997.1}.
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DR EMBL; MVGT01000456; OVA16997.1; -; Genomic_DNA.
DR STRING; 56857.A0A200R2P2; -.
DR InParanoid; A0A200R2P2; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OVA16997.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1918..2586
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2692..3003
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3016..3049
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1863..1896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1888
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3049 AA; 346217 MW; 252F0546EFFED5DB CRC64;
MVTTGDIEEI ISKLSSDKAK TREEGIKLLS SWLEGERSFG FCKFLSQNTA KLKPNEIPHS
KTWPFLLKVL IGCISSEIST SKKRPPKLVF AKTLRISIQQ AEDTKFSGKM QLLLSVVKSL
FSHIWDVLRD VPSFQSEYGI ILRHLLAVKD YRFHMRKRVY CGLVLLYMEK VGTSLSGKNN
VQSNPKEEVF RCILTLHSLL ENPPGDFPDN LREDIVKGFV GIFLHIRDEG KISRKLIECI
NVYLSKDGPN LDCKPMEIHS AVQEFVFRCW LTTHDRALKD ALILYATLQL KLTRSAADGC
HLVEQLIDIV GKELDQSNIA SSTIPWGDTA RDDKLGTLTS LHCGLLELAA SVFYWACINT
AKAPYSDKRP RREPAATRLR QGLMKGKWLW NGAFCFLIRI YHSRISKDLL IYWFEGICES
FERILNDGNS EHSYDGLLWV LRSLQELCYV RLLSIPRGDT SQCSSLTQNE IGGGWNRIWS
FLIHGLPIFS NVTSVVSLFF MFLEFLSHIV VSQELVNIPT VPHDVWDLRL FKHIPSVSAL
YFIACYFSRK GSQGDLRDIL HLRQNLLRSV LGLLNWKESF VLNESVIVLL PAAMFSLCAG
SAPFPHCLKV PFMSNSSIDV SEATEDRFKV EEHDHDLLYE PVECSVEVLA EIKPVSSVEV
SQSQCHHNVR LPRQIWHPLL HEMETHFLLV VMDKEIEKML LSDLFFLGGL LCNCIHGSIL
TRLIKANSSF VTKMCEHLLK LLQRAVSVIE ENKNDLQLHG CFGSSPILDG TGPTLASLRT
LVCSSLFSSW RDQNIFDDML SGAIIQVIEK LLRALGKLFE QFSEGTRHAQ SEIAMPEFFS
ASETCPPNSY PLDNCKVRIV DMDLDVNEDS KDMDIVGITR KGISVAPLSS VKWKFDMISA
MTNFFTVLPI ITWEIMFDLM EKENDSEVCE YILYSLCKHL SCSFTKLSDL VICMDNMIEV
RVSLKLRCVN ILTATCGLLG TLVSSGYGGK DKKVNLSALG RPSEQSLESL RDLVIKIAEF
DLLDWLGRVK LIDCICNFIT LDPPIGQQVM IEKLLTMLQD TDYRVRLFLA RRVGVLFQTW
DGHDELFQDV CSNFGVKLVM SSTKTLVTAM EVLAAGPYPR PTMETIIVTL AHLAFYSEKI
ELEAIFMICV VAAIDPCQRE LVFAVLDNLS SQLQYATRSK YLDELMGVIL FSWVACNVSV
VALVEIRDLF VLKSEPSYFM QYCCPWLLPA LIMSGDTASL KWVATVAGQP LAVLVKSHFV
PIFGVCMALH CSKKLGREKG AVVLQSSILR IAEISENDRD NLIKQHMVSI VSFILSLSSS
SSGPGMPFFP KDVIVQAIQT VVDGFLDMEH RPSTVGIVDK INIFRADRVF KFIVEIHYKV
TAAIHHRHRC HRFSGLEALI DIIGHRAAIS STSNYLFNLV GQFIGCHALQ DQCCLILSML
LEAFKSNPTK DVTCVLGEQL QFLVSKLVSC CIPSQNNGEL SSIPSSQVTS LLHQLIVDSD
PSLYDYIREL EPFPEIDCFD GIRKFHQELC KDYSTRDHFL KFVRRTSYLP QRLVLWSLQA
LHKKLLTGEI IRPEKNVENT VGQFSCWHCE PELVSAVWAL VRMCGSNDAN DIRALVSDFI
SRVGIGDPHV VVFHLPGDPG QMLLSQPLDH GSASEVGFNA DTGIPEELLI TLVKLLKKYL
LDESVNIIDM TSRALRGILS TERGQRALLS LDSYERSLIT VHSKGVNMEL VEKLLSHSER
KSSAEMRSLE NSSLWKTHGK SYETWICPLV HSLIDFSNDT ILRLCQDIVL LKAELAELLF
SSVLINLAGG KDSNVDLCKL ISSQVQENIF IETNELIKSV QVMLDALNEL RLYHVMERGG
TSAPLKRESS KHDKPSSYSS RSRSTSEKSK DPSAISSPMT MSTYLWEKVY WLSIDYLLVA
KAAIHCGSYF TSVLYVEYWC EEQFNSLILG SPDFSALEML PQHIELLISA VTQINEPDSL
YGIIQSYKLK SQIITYEHEG DWSKALEYYD LQVRSAPAVQ MDGFRSNLLQ EHSHGTHQLS
FSRSEVEMRR KKSYIGLMRS LQQTGCTHVL DLYCQGLTSQ KSLFEHDSEF TELQYEAAWR
AGNWDFSLLH VEVDNPATRK HIKIDHFNEN LHSCLRALQE GDSNEFHTKL IDSKQELVLS
IHHASKESTE YIYSSIVKLQ ILDHLGMTWG LRWRPSSYKE IESHSEKQKV LFEPVIPTMH
QMELLNRDWT FILNQTQVHM ILLEPFIAFR RVLLQILNSK ECTIQHLLQS ASTLRKGSRF
SLAAAALHEF KLLSAGTEGQ QATSYICFLG RLEEAKLLRA QGQHEMAINL AKYILHHYQL
NGEASNVYRL VGKWLAETRS SNSRTILEQY LKLAVELAEP KRSTDKKCLA RQCQTHFHLA
HYSDALFRSY EERLISNEWQ AAMRLRKHKT KELEVLIRRL KSSTKGEKTD YSVKIQELQK
QLAMDRREAE KLQDDRDNFL SLALEGYQRC LVIGDKYDVR VVFRLVSLWF SLSSRQNVIN
GMLSAVKEVQ SYKFIPLVYQ IASRMGSSKD GPGPHSFQFA LVSLVKKMAI DHPYHTIFQL
LALANGDRVK DKQRSRNSFV VDMDKKLAAE NLLGELSSHH GAIIRQMKQM VEIYIKLAEL
ETKREDTNKR IPLPREIRSL RQLELVPVVT ATFPVDSSCQ YHEGSFPHFK GLADSVMVMN
GINAPKVVIC LGSDGHRYRQ LAKSGNDDLR QDAVMEQFFG LVNTFLQNHR DTWRRRIGIR
TYKVVPFTPS AGVLEWVDGT IPLGEYLLGS LKNGGAHVRY GVRDWSFLRC REYMAKASDK
LKAFQTVCEN FRPVMHYFFL ERFLQPANWF EKRLSYTRSV AASSMVGYIV GLGDRHSMNI
LMDQVTAEVV HIDLGVAFEQ GLMLKTPEQV PFRLTRDIID GMGVTGVEGV FRRCCEETIS
VMRTNKEALL TIIEVFIHDP LYKWALSPLK ALQLQKETDD DIPILEDSQD VYEGNKDAAR
ALMRVKQKLD GYEEGEMRSV HGQVVQQLIQ DAIDSERLCQ MFPGWGAWL
//
