ID A0A200R3Q4_9MAGN Unreviewed; 1036 AA.
AC A0A200R3Q4;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 28-JUN-2023, entry version 20.
DE SubName: Full=Retinoblastoma-associated protein {ECO:0000313|EMBL:OVA17341.1};
GN ORFNames=BVC80_1837g150 {ECO:0000313|EMBL:OVA17341.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA17341.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA17341.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA17341.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA17341.1}.
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DR EMBL; MVGT01000438; OVA17341.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A200R3Q4; -.
DR STRING; 56857.A0A200R3Q4; -.
DR InParanoid; A0A200R3Q4; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF17; RETINOBLASTOMA-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 92..240
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 425..626
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 763..873
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
SQ SEQUENCE 1036 AA; 114624 MW; B69F05C88F0F286C CRC64;
MSSSSFEMED VKPSISKSYS QFVVDGALEV RFTELCKTMP SIDENTCSQA MNLLNESKHL
LLANMSAIGG GMPEEIERFW FAFILYSVKR LSEGKTVKEN QESDVKGLTL CQILRATKLS
IVDFFKEMPQ FNLKVGPVLK KLYGADWEKR LEAKELQTNF VHLTLLSKYY KRVYGEFFLT
SVADSDKKQA VASITGNVSN YQRFGWLLFL ALRAHAFSSF KDLVTCTNGL VSILAILILH
VPLCFRNFCV HESPRFVRRG DKGVDLLGSL CDMYDTSEDE LRKTIDKANN LIIKILKKKP
RLASDCRTKN LDNIDTDGLT YFEDLMEDSS SLSTSLIILE KDYDDAVHNK GELDERVFVN
DEDSLLGSGS LSGGAINICG SKRKFDAIAS PSKTITSPAS PLRSPAASPA NGNLLVANVK
VAAATPVSTA MTTAKWLRTV ISPLPSKPSS ELERFLSSCG RAVLNDVIRR AHIISKAIFP
SNTIGERCLA ENPQNANMMD SIWAEERRGE ALKLYYRVLE AMCKAEAQIL HVSNLTSLLS
NERFHRCMLA CSAQLVLATH KTITVLFPAV LQRTGITAFD LSKVIESFIR HEDTLPRELR
RHLNSLEERL LESMVWEKGS SMYNSLIVAR PALSAEVNHL GLLAEPMPSL DAISTHTNIS
YGGFPSLSLF RKPETSLGQN GAIQSPKRVC GDSRSVLVER NSFTSPVKDC LLACNSLKPK
FPAPPLQSAF ASPTRPNPGG GGETYAETGI NIFFSKIVKL AAVRINDLVE RLQLSQQVRE
TVYCLLQQIL SRRTALFFNR HIDQIILCSF YGVAKISQLS LTFREIIHNY RKQPQCKPQV
FRYVFIDWSS TCRNGKTGQE YVDIIAFYNE IFVPSVKPLL VELGPIATLK SKQPPEAKNN
VDAGQCPGSP MLPPFPSLPD MSPKKVSATH NVYVSPLRSS KMDALITQTS RSYYACVGES
THAYQSPSKD LTAINNRLNG KKVIAKLNFD DVGMVSDSLV MGILYRQNGS CAASSPAAAA
TATASNSPLK SQQPNS
//
