ID A0A200R552_9MAGN Unreviewed; 820 AA.
AC A0A200R552;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Peptidase M41 {ECO:0000313|EMBL:OVA17835.1};
GN ORFNames=BVC80_1835g227 {ECO:0000313|EMBL:OVA17835.1};
OS Macleaya cordata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC Macleaya.
OX NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA17835.1, ECO:0000313|Proteomes:UP000195402};
RN [1] {ECO:0000313|EMBL:OVA17835.1, ECO:0000313|Proteomes:UP000195402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC TISSUE=Root {ECO:0000313|EMBL:OVA17835.1};
RX PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT Benzylisoquinoline Alkaloids Metabolism.";
RL Mol. Plant 10:975-989(2017).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVA17835.1}.
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DR EMBL; MVGT01000437; OVA17835.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A200R552; -.
DR STRING; 56857.A0A200R552; -.
DR InParanoid; A0A200R552; -.
DR OrthoDB; 9585at2759; -.
DR Proteomes; UP000195402; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF2; SD01613P; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 366..506
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 102..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 90479 MW; EAA3602D048A5423 CRC64;
MIFSRLGRSV PRSARRIDRS GLLGGYGGRS SYLNGALLQS QDGSTSLGRE DIGLGLLRGY
LTSIGANKGI LSNSYLKDFK FALGNPRIHR FFSSEGPKKN YENYYPKDKK EIPKGSDQKA
DSKEDANTED HANFQDNFVK QFQNFITPLL FIGLVLSSFS FGPRDQKQIN FQEFKNKLLE
PGLVDHIVVS NKSVAKVYVR STPRTTNQTS DEVLQGRTEG VPAKGNAGQY KYYFNIGSVE
SFEEKLEEAQ EALGVDPHDY VPVTYVSEMV WYQELMRFAP TILILGSLLY MGRKMQGGIG
IGGGGGRGRG GIFNIGKAHF TKMDKNTKNK IFFKDVAGCD EAKQEIMEFV HFLKNPKKYE
ELGAKIPKGA LLVGPPGTGK TLLAKATAGE SGVPFLSISG SDFMEMFVGV GPSRVRSLFS
EARQCAPSII FIDEIDAIGR ARGRGGLTGA NDERESTLNQ LLVEMDGFGT TAGVVVLAGT
NRPDILDKAL LRPGRFDRQI SIDKPDIKGR EQIFQIYLKK VKLDHEPSYY SERLAALTPG
FAGADIANVC NEAALIAARN ESAKVTMEHF DAAIDRIIGG LEKKNKVISK LERRTVAYHE
SGHAVAGWFL EHAEPLLKVT IVPRGTAALG FAQYVPSENL LMTKEQLFDM TCMTLGGRAS
EEVLLGKIST GAQNDLEKVT KMTYAQVSVY GFSDKVGLLS FPQREDVYEM SKPYSNETGA
IIDGEVREWV AKAYKHTVEL IRKHKEQVAQ IAELLLEKEV LHQEDLVRVL GERPFKSSEP
TNYDRFKQGF LEEEKSIKST EGESVEDDGS SPIPPGVVPA
//
