ID   A0A200RC73_9MAGN        Unreviewed;       557 AA.
AC   A0A200RC73;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   08-NOV-2023, entry version 14.
DE   SubName: Full=Carotenoid oxygenase {ECO:0000313|EMBL:OVA20276.1};
GN   ORFNames=BVC80_157g76 {ECO:0000313|EMBL:OVA20276.1};
OS   Macleaya cordata.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC   Macleaya.
OX   NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA20276.1, ECO:0000313|Proteomes:UP000195402};
RN   [1] {ECO:0000313|EMBL:OVA20276.1, ECO:0000313|Proteomes:UP000195402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC   TISSUE=Root {ECO:0000313|EMBL:OVA20276.1};
RX   PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA   Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA   Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA   Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA   Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT   "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT   Benzylisoquinoline Alkaloids Metabolism.";
RL   Mol. Plant 10:975-989(2017).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006787}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OVA20276.1}.
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DR   EMBL; MVGT01000143; OVA20276.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A200RC73; -.
DR   STRING; 56857.A0A200RC73; -.
DR   InParanoid; A0A200RC73; -.
DR   OrthoDB; 318119at2759; -.
DR   Proteomes; UP000195402; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR   PANTHER; PTHR10543:SF141; OS06G0162550 PROTEIN; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR604294-1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00022964};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195402}.
FT   BINDING         222
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         271
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         335
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         551
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ   SEQUENCE   557 AA;  62092 MW;  45DF35AF5788F2A5 CRC64;
     MALSTSCLAF HQVVVVVNGS VRKPLISPNF DLLTTSLAST VKSNFAPVQE IGDAVNIVNI
     EGNIPVDFPN GIYIRNGPNP VFGGLKSTIS VFGKSSHTWV EGEGMVHALN LIKDGHGSWI
     VSYKNRYVET ETLKLEMQRN KLCFLPAVEG DTPAILAAYV LNLLRVGKVN KFISNTNIFE
     HSRKFYAIAE NHLPQEIDIN TLGTFGSWDV NGAWNDRPFT SHPKKAPGTG ELIITGVDAL
     KPYFVLGVIS ADGKKLVHKV DLKFNRSSLC HDMGVTQKYN VIIDSPLSIS INRLLRGGSI
     LKYDKEGYAR IGVMPRYGDA NSVLWFQMEP HCTLHILNCF EDGDEEVVVR GCKARESIIP
     GPEFGLNKFE WFSRGFKPIC SSEKEEEEDG FLFTRLYEWR LNMKTGGIKQ RYLTGTSFSL
     DFPFINLNFV GIKNKYGYVQ VVDSISSSDC GNINFLQFPY LHFEQKESQS GSGFEAIKVE
     YHKLGKNTFC SGAAFVPNPE PGSEEDDGWI ISYVHNEDTN ISQVHIIDAK KFESEPVAKI
     TLPQRVPYGF HGTFASI
//