ID   A0A200RCX5_9MAGN        Unreviewed;      1050 AA.
AC   A0A200RCX5;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Cytochrome P450 {ECO:0000313|EMBL:OVA20568.1};
GN   ORFNames=BVC80_1065g125 {ECO:0000313|EMBL:OVA20568.1};
OS   Macleaya cordata.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC   Macleaya.
OX   NCBI_TaxID=56857 {ECO:0000313|EMBL:OVA20568.1, ECO:0000313|Proteomes:UP000195402};
RN   [1] {ECO:0000313|EMBL:OVA20568.1, ECO:0000313|Proteomes:UP000195402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BLH2017 {ECO:0000313|Proteomes:UP000195402};
RC   TISSUE=Root {ECO:0000313|EMBL:OVA20568.1};
RX   PubMed=28552780; DOI=.1016/j.molp.2017.05.007;
RA   Liu X., Liu Y., Huang P., Ma Y., Qing Z., Tang Q., Cao H., Cheng P.,
RA   Zheng Y., Yuan Z., Zhou Y., Liu J., Tang Z., Zhuo Y., Zhang Y., Yu L.,
RA   Huang J., Yang P., Peng Q., Zhang J., Jiang W., Zhang Z., Lin K., Ro D.K.,
RA   Chen X., Xiong X., Shang Y., Huang S., Zeng J.;
RT   "The Genome of Medicinal Plant Macleaya cordata Provides New Insights into
RT   Benzylisoquinoline Alkaloids Metabolism.";
RL   Mol. Plant 10:975-989(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OVA20568.1}.
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DR   EMBL; MVGT01000078; OVA20568.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A200RCX5; -.
DR   STRING; 56857.A0A200RCX5; -.
DR   InParanoid; A0A200RCX5; -.
DR   OrthoDB; 2434474at2759; -.
DR   Proteomes; UP000195402; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0033075; P:isoquinoline alkaloid biosynthetic process; IEA:UniProt.
DR   CDD; cd11072; CYP71-like; 2.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 2.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR47956:SF10; CYTOCHROME P450; 1.
DR   PANTHER; PTHR47956; CYTOCHROME P450 71B11-RELATED; 1.
DR   Pfam; PF00067; p450; 3.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 2.
DR   PROSITE; PS00086; CYTOCHROME_P450; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195402};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        577..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        992..1011
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1050 AA;  119535 MW;  7B93322916635377 CRC64;
     MALSFLVFLQ LLEEQQGLFS QIFTLSSLVL FFSVLFLLKH NGALSSKKSN NPPPSPPKIP
     IIGNLHQLGT LAHQSFRDMS HKYGPLMLLH MGQFPTLIVS SPEMATEIMK NQDPDFANRP
     FTTAAKAFLH GRLDIGFAPY GEYWRQVRKI CVHELLSIQR VQSFRFVREE EVGALIKKIS
     SSCSRGDVIN LSEILPTISN NIVSRCTFGG KYEGSHENRF GQLSRQAMKL MGAFCFADFF
     PSLGWLDFFT GLTGKLKRTS QELDSFFDKV IDEHLLPKSK NHSQQEDKED LIDILLLAQK
     DNSNLSRDSI KALIMDMFVG GSDTTATTME WAMAELIKNP KLMKKAQDEV RRVIGKKSKI
     EEDDINQMDY LRCIIKETLR LHSPLPTLVP RQSFNKSTKV QGYDIPPNTR VFINAWAIHR
     DSKLWDNAEE FRPERFINNP IDFRGQEFHY IPFGSGRRVC PAISFGLASL EFVLANLLYW
     FDWELPSGEN RDELDMSEAL GLTVTKKIPL HVVPTLKNIF YCTSHHNIKK KLSNKIINTI
     YKFIKGIISV LMQPSHARMA PSLLVFLQLL EAQQVSFLQI FILSILVLFF SVFFLLKLHG
     AWSSKKSNNP PPSPPKIPII GNLHQLGTLP HRSFRDMSHK YGPLMLLHMG QFQTLIVSSP
     EMATEIMKNQ DLVFANRPFT AAAKAFLYGC IDIGFAPYGE YWRQVRKICV LELLSIKRVQ
     SFRFVREEEV TVLIQKISSS CSRGDVINLS EMLLTVSNNI VSRCALGAKY EGAHENRFGE
     LSRQAMKLMG AFSFADFFPS LRWMDVVTGL SGRLKRVSQE LDTFLDQVID EHLLPKSKNH
     NQQEDKEDLI DILLLAQKDN TNLARDNIKA IILDMFVGGS DTTATTIEWA MAELIKNPKL
     MKKAQDEVRR VIGKKSKVDE DDINQMDYLR CIVKESLRLH APIPTLVPRE SSKSTKIEEE
     FRPERFINNP IDFRGQEFQF IPFGSGRRGC PGVSFGLAVL EFVIANLLYW FDWELPSGTN
     RDELDMTEAF GLTVNKKIPL HVVPTFHSAS
//