ID A0A208XPL4_9BURK Unreviewed; 813 AA.
AC A0A208XPL4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Penicillin acylase family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDO44_15965 {ECO:0000313|EMBL:OVZ57881.1};
OS Pigmentiphaga sp. NML080357.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Pigmentiphaga.
OX NCBI_TaxID=2008675 {ECO:0000313|EMBL:OVZ57881.1, ECO:0000313|Proteomes:UP000196551};
RN [1] {ECO:0000313|EMBL:OVZ57881.1, ECO:0000313|Proteomes:UP000196551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML080357 {ECO:0000313|EMBL:OVZ57881.1,
RC ECO:0000313|Proteomes:UP000196551};
RA Bernier A.-M., Bernard K.;
RT "Pigmentiphaga species Genome sequencing and assembly.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR001227-2};
CC Note=Binds 1 Ca(2+) ion per dimer. {ECO:0000256|PIRSR:PIRSR001227-2};
CC -!- SIMILARITY: Belongs to the peptidase S45 family.
CC {ECO:0000256|ARBA:ARBA00006586}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OVZ57881.1}.
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DR EMBL; NINW01000037; OVZ57881.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A208XPL4; -.
DR OrthoDB; 9760084at2; -.
DR Proteomes; UP000196551; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR CDD; cd03747; Ntn_PGA_like; 1.
DR Gene3D; 1.10.1400.10; -; 1.
DR Gene3D; 2.30.120.10; -; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR Gene3D; 1.10.439.10; Penicillin Amidohydrolase, domain 1; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR014395; Pen/GL7ACA/AHL_acylase.
DR InterPro; IPR043147; Penicillin_amidase_A-knob.
DR InterPro; IPR023343; Penicillin_amidase_dom1.
DR InterPro; IPR043146; Penicillin_amidase_N_B-knob.
DR InterPro; IPR002692; S45.
DR PANTHER; PTHR34218:SF4; ACYL-HOMOSERINE LACTONE ACYLASE QUIP; 1.
DR PANTHER; PTHR34218; PEPTIDASE S45 PENICILLIN AMIDASE; 1.
DR Pfam; PF01804; Penicil_amidase; 1.
DR PIRSF; PIRSF001227; Pen_acylase; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR001227-2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR001227-2};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 224..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 278
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-1"
FT BINDING 357
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-2"
SQ SEQUENCE 813 AA; 87319 MW; 858AD5ADAF81D213 CRC64;
MTRRVASRAV RLAALATAGL VVLMVMSAAG AWLYLRASLP QLDGQVRAGT MQSATIARDA
QGSVTIRAQN RADAAYATGF AHAQDRFFQM DLVRRSAAGE LAALVGEAAV PMDRRVRLHR
FRTRAERAYA ALPPAHRTLL ERYADGVNAG LASLDARPFE YVLLGAPPQP WQPVDTLLAI
YAMYLDLQGG ELVRTRSREA LRSLLPEPVL AALIPVGSRW DAPLDRPPSS APPEVPPAPA
LLDARPDWID RPRPPRTRGA TPAELMVDAG TPASALGSNG WAVDARRGAD GRALVANDMH
LGLRLPNVWY RLTLEFPSAA GQRRISGVSL PGAPIVVAGS NGDIAWGFTN SYGHFMDLVR
LDPDPADPTR YRGPADAWEP ASETMERIEV KDGPPVMLPV RETRWGPVLQ TGAHAYAVRW
IAHLPEAANV VLAEMENARD LGQALRVAQA AGIPTQNLVA ADRGGGIGWT LAGPLPAATL
DPLGFPAEPD RAGAPLARLA PADYPAIIDP AYGRLWTANS TQLADGDAQR KIGDGGADVG
ARATQIRDAL FAAERFNERD LLAIQLDDRA PWIAFLREQA LAVLDDAAVA DHPQRAAARR
ILQSWNGRAD ADSAGYALLR AYYDALYDAW FGALDDRLAA IEPGLSVRRA SSRLLAVMED
LVRAQAWKPA YAADWRAFML ERIDTSIAAL TAGGRPLEKI RWGDRNRLAI AHPLARVLPA
PVGRWLSAPR RPMPGDIHMP RVQGAAFGAS ERFVVSPGHE EHGVLEMPGG ASGHPLSPFF
LAGHSAWVAG EASPFLPGPD AHRLTLAPAE AGH
//