ID A0A210PGY0_MIZYE Unreviewed; 3594 AA.
AC A0A210PGY0;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Protocadherin Fat 4 {ECO:0000313|EMBL:OWF35739.1};
GN ORFNames=KP79_PYT10576 {ECO:0000313|EMBL:OWF35739.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF35739.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF35739.1}.
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DR EMBL; NEDP02076710; OWF35739.1; -; Genomic_DNA.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 22.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.60.40.60; Cadherins; 22.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR PANTHER; PTHR24028:SF340; CADHERIN 96CB, ISOFORM D-RELATED; 1.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 11.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 21.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF49313; Cadherin-like; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50268; CADHERIN_2; 23.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50923; SUSHI; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3555..3578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..294
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 301..398
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 398..522
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 514..614
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 633..735
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 740..839
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 847..944
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 951..1042
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1042..1152
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1174..1256
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1281..1322
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1334..1440
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1565..1656
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1641..1752
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1752..1854
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1871..1969
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2007..2110
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2118..2206
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2336..2424
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2642..2747
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2754..2860
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2867..2964
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2971..3063
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3064..3171
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3260..3301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3302..3338
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3343..3382
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3384..3420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 3328..3337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3372..3381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3410..3419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3594 AA; 394277 MW; 58EA525A4ABC607F CRC64;
MVIAEKGQGT GQGEQSQKVT VRESVARFFF STGFAQDRVA QSTVSSRTRE ISEQPMCDGT
SCPGLLETKP CREDALVNCS LTEWSTWSDC SNDCGEGSAF RSRTLLTPAY CGGAPCLQLP
LDESRECTSH RARQDCKVSN WHDWETCIRN CGEGVQIRRR VVEVPRLCGG GACSETTVSS
VNRKEISEVK SCHKKCTHIC KQSVCSCRTG NYLSADGVTC YPVQCSMPRV QYCPPSHSFT
SCRYPRFTCP SYSYGSNCTA SCAHYEKWEL RGSPSYVTCH ADGRWSQPKI YCSPANHKPT
KLTIDNSEIR ESLSAGAVVA YMSTEDKDGF DKHTYTIVND PTNRLAVKEH RIVIRVKPDF
EDPPTVWNAT IRSTDLDGLY VEDTFEFRIM DRNDPPTSVT LFPDTILENS LAGTHVGCLT
GQDDESGSNL TIILVDSHKN TFEMYEKDDE ICLKVAKQSN KRCSQDGGLY CVLNKEKRRK
VTVTVMATDT GDDPKSAYFD ITINLNNVND RPVSISLHPP NVPENITPGS PVADLMTQDE
DHQSKFKYEL LSGDTDIFYL SGKQLFSRET FDFEQQQSRK FEITVKSTDN GSPPLSIVST
IKFKVGDVNE TPYAIHLKSY NGQLHFEDNK PLVRENAKGV AMMGTIFVAD VDKNDNLTLS
LPQDADGRLA IVQQRCTARQ DVNVLCTATV AASGEFNYEL EPQVNVSIRA VDRGGLQTIT
HLSLHVEDMN DSPQDILIDG ESITNISVPE NANHYAMGKL EAVDEDEHDE HDFFLTNSAH
RKFIIENDIL KTYSAANLDY EEDKSYKIKI LVEDDGTPKL FHEKTFHVHV DDVNEAPTTL
SLSHNMVTEN SVEGTDVGRL STVDPDNARD TTQTFTYSLT DDSHGRFTVS HSIGQCGSAA
CLLDFESAPF VFLEVNVTDS GSPPLSTTNV FQIQVVDAND APHSVSLPDK TVRENSPVGA
LIGTLTSVEE DAGQSVSYVL LDNTNLFELK DGSNLISKSV YDYEEFSRYN ITVRATDNGE
HPLSVDTTIT IEVLNINEPP RFSGDVEFQV NENAAIYTPI GVLKFTDPDN EDQLVFTITG
TGNIFQVTNN ECQEQETTQD TICTGNLLLK EPLDYANRPE YTVTVTAQDR GGLTATKDIL
VRVMDDNNAP TNLVINGYSA SEIQVKENQQ DIGIGTLKAV DPDEGQTFKY SIESTDTGPF
EIVEDQLKVV AGASLDYESV KEYTLEIIVT DSGVPPQNFT KVLSIQIEDV NEAPSNLTIS
STQVAKPNGG CLQLGGDKCY LNFESAPLLH VSVLVTDNGV PSRSNQFEID VNVLDDNDSP
RNIQISSYKL EALAPAGEVV GTLTADDEDE KQSLVYSLID DNNGLFAVSN TGIVTKATDD
ALDIKKLYVI RASATDNGTN HMQTEELFTI IAIMKDITKM TLNMTSEGSE QIFADGLPVV
PENSPDDTVV GTLVATDQRP DQMLTIQITS QLTALKLDTK THCTNKDGGT ECKVMMLTAV
ELDYEFTSTV AIIGQVSDGH NQSYTHRFTL HVKNVNEPPE GLRFDGNRIF VQENLNGEVF
ELFIAQDPDR DEVLTFSLPD DGDGRFTITK DGHIATASDA NIDFEETPRI NITVAVEDSG
GLGTSKMYTV DISDVNERPG SITLTKGTVE EMAPSGTHVG IFESVDPDEG QTIAYKLLND
ADGRFSIDGN VLKVKDEGIL CAEKGGSYCL LDYESKTSHA IAVEASDNGS PVLRTTTMLN
VLLSDVNDAP RDLTLTLVNV REDTNIGEVI GKLKALDDDT DSSMSYAILA GDDEGMFSVD
AADVKLKKHM DYETTPRYNL TIQATDNGTP PQTVLGIFKL NIVDANEGPG VPSFQSKTGS
NNDFPANRPV VDENAALSTV IGQIVVLDPD DNDMITFTTT NTDVGLFHQE CWPLRKGVHC
TCDVRTMVLF DYETNPSVDV YITVADRQGL ATSLMVTLHI ADINDPPTVS QSYQFKYVSP
QGLDYELYPT HELVIRVTDN GDPPLHMDKH VTVNVPENSG VGFEVGTLIV DDPDNTRSNT
QTFTYSLKDS ADERFRLDGA SLTVARSDFD YEKKRMYQLH VLVTDTGSPP LSAGARVNVY
ITDANDAPRD AQLIGGIVAE NSEMGAVVGR FLATDDDSNQ HMTYSLLSND FFTVAGDELM
VDGDIDYERS SDITLKVIAS DDGSPPASVS INVTVKVIDV NEAPVNITLQ LSDKVQDMMI
PEALEPGERI GSIHVTDPDH HDRIRLKQIG DSTALFKVSQ HPLCTQSPMK YHYTECEFDL
ILEQALNFEG GNSNITVEIE ASDILGETLK ISWEFGVKNS NEPPSNIFID GDIKDIPENS
PNFFLGSLNT IDEDEGDEFA YQILTHWEIF RIYKNRLYAV TPLDHEAEHS VTVSIKSIDN
GSPPLSLIKE FSFDVGDKNE VPTNIALSHT EVSNAASPGD VVGFITVTDP DNEGVDTPVQ
IHTCTVGGDA LGFFTVEPST PLAFKVTKDI PKDILEMLLR LTCTDDGNPV LSLTVDITLT
INETVTIQKG LRLRNQRTIP ENTDAHFVVG KLEVVNILTE EAIEGTYTYT LSNEQLPFGT
NGANLETSLS LDFEHQSEWE IDIVTSGVDI RNRDVHITET FIEVEDINEA PYKINIYGGG
LVLENSDPGT EIGDLNSEDQ DDDQTYNYTI IAVSPGLDMS QVRPELKDTF NLKGKTLVVG
GNSEELNYEV VKYFTLLIQT TDSGNTPLSY NDTIHIQVQD SNDVPTDILL TQNTIQENSA
VGTVVGELNL VDEDALLSYT CVVINPKNAP FKVVTVTLVG GGESSVFSVD GDSTIVANEV
LNFEKQAEYS IIIRATDDES LWSEETFTIK VQDKNEPPSA VVLDSKSVDE NTGPGHIIGT
LTTMDDDNGQ RFNYVIVDDP THSALGYFKI EGDKLVTGET PLDHEMQSEY TIVIKSTDNG
DPAYSVETQI KIKVENINEE PEDIIVGALL TLPENANSHA VVTSVEVDDP DIGQHHICQV
EPTSLPFSIK TFADHHMELI LNGALDYETK EKYDVTIRCS DGVLERKKSV QVLVSDVNER
PEAIQLSGTG SIIASARPGS VVGIFSVLDP DPHQTHTLTL SGPNSDLLQI ERSSVTLAAP
IPDEIVYAEH PVLSINVTAT DNGVPEPLSV QQIFTVVITN VQVVVKQLPV ITLRKVEILE
DTKPGKSIGP LLNANVSAGD IDFKITRNPF GAFKISKNIS LILDKNLTGV EGDSMKVTIE
VINRETFKSA FTDILVFILR IDKCKRHTNK TCDEHARCVQ HNDTYDCECE TGYTGDGYQC
TRNTYCDVNP CDSGGRCVDG IAAATCLCSD GYSGPQCEIS NDSSNPCLKS PCKQGGICSL
NDTLSVGYEC ECEPGWEGTT CEESVDDCIS SICYGGGQCV DKHITYICQC PLFRTGTRCE
YFRSSCENVS CGSDICVPMV DRDESTCATE KSELVHLQVR KNQGKFDKEA FQSWLIDTIT
AFYRRSAGGS VEKTRVRRQT VTETTVQVIS SKYKITVLLR VLGKDQNDEK VLCPAVNKAL
VSDNGKSTED TGSPVGVIAG AAAGVVVLVC VVVAIVIYRK RKQRGDSSDK DTLK
//
