ID A0A210PHX3_MIZYE Unreviewed; 216 AA.
AC A0A210PHX3;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Metalloproteinase inhibitor 2 {ECO:0000313|EMBL:OWF36085.1};
GN ORFNames=KP79_PYT11741 {ECO:0000313|EMBL:OWF36085.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF36085.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF36085.1}.
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DR EMBL; NEDP02076678; OWF36085.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210PHX3; -.
DR EnsemblMetazoa; XM_021485581.1; XP_021341256.1; LOC110442123.
DR OrthoDB; 5403389at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF25; NETRIN MODULE NON-TIMP TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..216
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012374482"
FT DOMAIN 23..151
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT DISULFID 23..89
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 25..117
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 37..151
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 154..200
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 159..166
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 174..191
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 216 AA; 23798 MW; 72BFD39B6E978B83 CRC64;
MTLLSVLLFG VLLLCGAHTV FGCSCAPSPP HRQLLYCNND IVFIGKIREV LPAASMDDDH
IYHVKVRRVF KGNISGVITV KTPNNGGMCG ITGLVKKEKY LMTAKSNNDG TYQIQLCQSL
ILNKNSVTNE VKRKYNSNRR YSFPGLNDIN CKTCKIVYCG ESKDGCGSNR PTTCTYYGDY
TKIQCFNKLR CIPSASGKSC RWSSPVCGRP GDITIG
//
