ID   A0A210PIW2_MIZYE        Unreviewed;       905 AA.
AC   A0A210PIW2;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   22-FEB-2023, entry version 20.
DE   SubName: Full=Iron-regulated protein FrpC {ECO:0000313|EMBL:OWF36425.1};
GN   ORFNames=KP79_PYT24656 {ECO:0000313|EMBL:OWF36425.1};
OS   Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC   Mizuhopecten.
OX   NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF36425.1, ECO:0000313|Proteomes:UP000242188};
RN   [1] {ECO:0000313|Proteomes:UP000242188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX   PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA   Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA   Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA   Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA   Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA   Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA   Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA   Chourrout D., Li R., Bao Z.;
RT   "Scallop genome provides insights into evolution of bilaterian karyotype
RT   and development.";
RL   Nat. Ecol. Evol. 1:120-120(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWF36425.1}.
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DR   EMBL; NEDP02076620; OWF36425.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A210PIW2; -.
DR   Proteomes; UP000242188; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        252..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          37..169
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          491..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..574
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        611..651
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  99428 MW;  6AA314CB47B1325D CRC64;
     MSGDEIVPLL PEVNIEPANN VCQQRTIRPQ RSLPPGKTYH IFISYSSHDE SYVLRLKNVL
     EGLGFKCMLA EHDFSYGVSV MRNIETTIQT CHKLLLVVSQ HFLQSAMCDK EVDMAHKYAA
     DIGRNDFMIV LRLDESKMPL KLDYMTYING AELEVKDVGR KVEKAFDGFA DVPLPPNING
     QEIIRCQPTE TSHRLWCSSS YEFGDLSQYE RNMLLAWSVE ESQTCYREIV EDANDHFLLK
     RYAVFAFDRK SLCFWVLLAL GIVTLSASLY FLITKLNGTD TFLNDLLIIF ICSISFTTGL
     YTGCTVYLFH QMMRRLYSIV RKNTDCKSQN YIVIPRQHRN ALFISFIYYD MKRCWNYLKQ
     RARENWPDDS EEDIANKCNE ELVTTILGSF KGSDWNPIPQ AASIRHNTYQ NRCCLCMVAK
     SSWTYRKSAL NVTLDQGIEN NQDEETCVMK IAESETEHET FVKNTFEIDH EHFESTEEND
     ETSVKKIVCN RQESNSSDSH VAGAVSGSPR TEAGSGFLLT GAEFGKSSLR GAKGDTSLRG
     AECGTSLRGA EGDTSLRRAE GGTSLRRAEG DTSLRRAECG TSLRGAEGDT SLRRAEGGTS
     LRRAEGDTSL RSAEGGTSLR SAEGDTSLRS AEGGTSLRSA EGDTSLRSAE GGTSLRRAKG
     DTSLRGAEGG TSLRSAEGDT SLRSAEGEGD TSLRRAECGT SLRGAEGDTS LRRAEGGTSL
     RRLEGDTSLR GAECGTSLRG AEGDTSLRGA VGGTSLRRAE GDTSLRGAEC GKSLRGAEGD
     TSLRGAEGGT SLRGAEGGTS LRGAVGGTSL TEAVGGSSLD SNIDRWYGNM CETRVRGEAT
     SKQQPQVSHE LITWRGNPVN LTDSEISTSL NDREEAVPPQ SGDEELQWYR GEHVIDEAIH
     AKVPR
//