ID A0A210PU91_MIZYE Unreviewed; 1553 AA.
AC A0A210PU91;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Multidrug resistance-associated protein 1 {ECO:0000313|EMBL:OWF40077.1};
GN ORFNames=KP79_PYT06510 {ECO:0000313|EMBL:OWF40077.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF40077.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF40077.1}.
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DR EMBL; NEDP02005488; OWF40077.1; -; Genomic_DNA.
DR STRING; 6573.A0A210PU91; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18595; ABC_6TM_MRP1_2_3_6_D1_like; 1.
DR CDD; cd18603; ABC_6TM_MRP1_2_3_6_D2_like; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF443; MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 985..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1036..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1134..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1219..1240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..522
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 616..841
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 993..1276
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1313..1547
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 277..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1553 AA; 174391 MW; 7EA3732F5AA8D3E1 CRC64;
MSIVLPVLDS SMDERGGGFC NSPFIDEQQS WNTTDPDFSP CFQKTVILWI PCAFLVLVTP
FHIYFLTKSQ APTIPSSCLS ILKTVLAVLL AVAAIADIGK SVQQFISEEP VPTVDFISPL
IFCLTMVLAT FLIQHERKHG VQSSGVMFLF WLMLLTSGIL IFQSKVRTAA GEGIDEVFRF
VIFFIEFPVI LIQFILTWFV DRRKNEFVPT AVVHDKPCPE ADSSFISRIS FWWFSGTVVQ
GYKHALKRSD LFAMNEEDMC SSVIPHFDKY WHQEIEKEKS SKRNPETPST DGIELQTRQR
DGETYTEVNV VDGKPPYKAK LLISLIKAFW PMFLLSALYK LIFDILQFVS PLVLKQLIMF
TRNKSEYQWR GYVYAVMMFV VAVVQSFILH QYFHGCQLLG MKLRTAIITV VYRKMLLLSN
TARRNSTVGE IVNLMSVDAQ RFMELMTYFH TIWSGPFQIV VSLYFLWQTL GPSVLAGTGV
MIVMIPVNAV IAKKSRDLQM QQMKFKDSRI KLMNEVLNGI KVCRDTKLNH ICRQYVSLVT
FAVYVLVDSN NILDAEKAFV SLSLFNILRF PLSMLPQVIS SIVQVSVSVK RLQHFLDNEQ
LDIFSIDRDT SAKHSITIEK GTFTWEKETE TPTLREINLE VPDGSLVAVV GSVGSGKSSI
LSAILGEMEK LKGKANVKGS IAYVAQQAWI QNATLQDNIL FGKTKYQTEY SNVLDACALK
TDLEILPAGD ETEIGEKGIN LSGGQKQRVS LARAVYQDAD IYLLDDPLSA VDSHVGKHIF
DQVIGPRGLL KEKTRVLVTH GIGFLPKVDL IVVLVNGQIS EVGSFQELIG HAGAFAEFLK
NYLTEELDSE DVDLDLEEIE DLKMAEEIVS QLGSIMEDDK TAKLQKQVSV ISSRLRTMSG
GSQDLDGDVP RAVTPVSWKG SQPKFPTSPV LMRQKSEHPV SKEEKEAENL KRQVQEKKKE
DKLIQAESVE TGTVKMTVFL SYLKSVGPIL SCIIILFYIL YNIASVYSNI WLSEWSNDEA
ATVNGTVDTA QRDLRLGVYG ALGLVQGTVI VFASLCLYLG NVMAGRHLHA GMLKNIMASP
MEFFDTTPLG RMVNRFSKDI DVLDVTIPRT FEAWLACLLR VLSVPVVIGY STPLFLTVLI
PLGLLYFVIQ RFYVATSRQL KRLDSVSRSP IYSHFGETVT GVTTIRAYKQ QERFISESEG
KVDENNICYF PSIIANRWLA IRLEFVANCI VFFAALFAVL GRDELSAGLV GLSITYALNV
TQTLNWLVRM TCELETNIVA VERVKEYSET PTEAAWEIED KKPDPKWPET GKVTFENYGT
RYREGLDLVL KGITCEVQPG EKVGIVGRTG AGKSSLTLAL FRIIEKAQGS IIIDGIDIAS
LGLHDLRSKI TIIPQEPVLF SGTLKMNLDP FEQYSDAELW RALEHAHLKS FVKELPTELM
YECSEGGENL SVGQRQLVCL ARALLRKTKI LVLDEATAAV DLETDDLIQN TIRTEFHDCT
ILTIAHRLNT IMDYDKIMVL DAGVIREYEI PHILLQDKET IFYGMAKDAG LVF
//
