ID A0A210PY45_MIZYE Unreviewed; 4136 AA.
AC A0A210PY45;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Kielin/chordin-like protein {ECO:0000313|EMBL:OWF41369.1};
GN ORFNames=KP79_PYT07777 {ECO:0000313|EMBL:OWF41369.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF41369.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF41369.1}.
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DR EMBL; NEDP02005405; OWF41369.1; -; Genomic_DNA.
DR STRING; 6573.A0A210PY45; -.
DR EnsemblMetazoa; XM_021516601.1; XP_021372276.1; LOC110462590.
DR OrthoDB; 2906064at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00109; Kunitz-type; 2.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 6.20.200.20; -; 14.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 7.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 2.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 2.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46698; CROSSVEINLESS 2; 1.
DR PANTHER; PTHR46698:SF4; CROSSVEINLESS 2; 1.
DR Pfam; PF00264; Tyrosinase; 3.
DR Pfam; PF00093; VWC; 14.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00131; KU; 2.
DR SMART; SM00214; VWC; 30.
DR SMART; SM00215; VWC_out; 12.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57362; BPTI-like; 2.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57603; FnI-like domain; 25.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 2.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS00498; TYROSINASE_2; 1.
DR PROSITE; PS01208; VWFC_1; 11.
DR PROSITE; PS50184; VWFC_2; 22.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..4136
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012148689"
FT DOMAIN 282..360
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 324..360
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 366..418
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1044..1085
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1092..1142
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1920..1978
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1979..2037
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2092..2150
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2151..2213
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2213..2272
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2332..2389
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2389..2451
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2451..2511
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2508..2571
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2571..2630
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2640..2700
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2816..2873
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2990..3051
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3242..3299
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3299..3356
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3363..3419
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3419..3476
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3476..3534
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3534..3597
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3661..3725
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3730..3790
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 3794..3969
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DISULFID 350..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1075..1084
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4136 AA; 460974 MW; 75407DEA397D9D6E CRC64;
MIPRGKMISV TWKILLISLV LACHVEAGGG KKRPSKKEMD FVRLIRKVKD SPGVEKLTPK
GFKLTDKWDP KILKSKAVRK FWRKYRGDLS YYISGQSDQG LKSVPLLSIY HHKKLLPILE
VSINMKSRKF IVRYQGKVSF QRKEVELSAP VMKFFSVLLH VNQTSLVLRH GCEAEHVIQL
SQPMMKIPST AKVSLSDPRK SQKFTGLLFD AKLFAYITRK PRTCTQYQAM QRDESITSKD
KASAKYRYGD EPDIQEIVNN LEIENMYLKE ALKSLDQCVC YPQCIVDGVV YDDGDTWQQN
FCTICVCEKG QPSCSPRLDM ANCTAPCTDS PCKNQGSCVD VGMDGYHCDC MAPFDGPTCE
VRQNPCVWPL EMGCCDGNNT VIRYFYDRFT EDCLPFNYSG CGGNVNNYET IEQCRSVAMT
GACCFRRFKT DVDALIEGEQ GEESKCEILS IGDCRSLHGD ERLGYQLEVT AFAPGQLCEE
VNCLMPSDKC MYDGQTYSPG DKIPQGCQDC MCEADGQWTC SCKVVSERKE IRDMTREELV
KFYSAIQQLR LTGPGNEWEK LRDLYMTHSM QANGGHFYLP WHRIFLRRLE QKLQRIDCSI
TLPYFDFTTD AGRFADAIIW QPNYFGGNGE VDSCVPDHSF GQPGSWRPCI MRKFDMSVPI
PSLADLSIAI SSENFLGMSM FLETFLSYVH RYIGGDMLTT GAPYDPIFYS VHAFVDMLYW
QWQQKGNNKN MFPGGYGNIP MVPFNIPARS VLDLEAEVCV TYALPSKGNP CNVTMNPGPE
LGRQPDRGDI PAVTVDLNLP GYEAGFDRRG FSQDGYGKDG FNRDNYDREG FNRCGYNRFG
VNREGYTKYG YDVEGFNRNN EEDTTGHYHT NGYNDFCLNR RGLTRDGYDK HGFTVGGIDA
NECSYYYKGP FATAQSLKIW DILSLQGQGF LKTFPRMCPP LDPVPISWAE QFWITQIKDV
SALAPSPIPN TERTLSATDA RFCFDTQSFL TPCTCETTVA SCVTNPCLMA SCPSWPEATC
RINFCTECRD VWFYDDQIVD CHGERDFCEP NPCQNGGSCV PSIWPTEPQL ITCTCPPGWD
GHLCQFPALD VCSLPINTGS LCGQESRWYY NPKSRACEEF VYMGCGGNAN NFPTLEACRG
RCSIGACCHR LPNFKNRNIG YGIQGYDRYG FNIKGFNRRG EPRTRNNSFY NGNDLYNSKG
YDWQGFDHFG YNKEGFDRFG YDRNGLDQEG FNLLGYSDIG DYDGNIDYNE EGYDSEGYDR
AGMNCQGHSR RGLNSQGVTV AYLYSCRSAS LDQCQNLEKV KGQEVIKFVP GQRCETTQCE
KSCGCSHGNM TYGFGEKFRR GCQTCTCLPS GSVICDCVNV RQRKEIRDMT REEMEKFQAA
IKHLAMETGH PSRWFSLARM YADHRPQAVG GEHFLPWLRY FLQFVEQELQ EIDCSLTIPY
FDWTVDVGDM RKSIIWAANM FGGNGETLEG CVRNHPFKDY HPPFWAPCLR RQFNTKISLP
DAVDVELLMR RQRYESFRLQ LEVMSNQFQA WVGGHMQTEL APYDPLFFSH MAFIDRLWSE
WQKRGGNGYF NYPQKLRYIS MVPFDVTPDD VMASEGQMCV AYLPLSEGAL CNTSVPLFGY
DSEGYDRHGY DREGYDRDGF NKRAMDRGGN PDMRGIFSTL GLDRHGYKRN GYDAIDFDRY
GFYYDMYNLD GVDSAGYDRD GYDRYGFNRN GMTPYGFLGN GTWTQGERLD LFDRFGYNRY
GYSSNGLDRN GYDVFGFDSV GFDKRMCNNF YLGPAYVIIK RWSDVELGKL DDLSLQIITR
ICPVVTMLPS WVYSSSWFVR GNQVAQIEAI QNRQQTDYTP RTSSVLENKL WLPVPSDHRL
CFVTNYYNTC PFGQLPVSCP DTCGDRQCPG IVDAVCRTNN CGHCHQEWYN GVTGNIIECS
GCVDENGKER PEGSTWAPSV CRVCTCQQGL QNCAETICTE PTCTHPIQIP GQCCKSCGGG
CDYNGDIYSN GEVFEESECN TCQCSYGSVE CRRKPCQLTP GCRSSSLLPG DCCPTCMDCG
SHGNGSRWRE RDSPCVEHTC LNGVSNQRRI QCEETNCQHP YTPAGDCCPV CVACFYQGRI
IQDGELFTPN LCTSCLCKHG NVDCIDEQCP RPQCSMPITA PGECCPTICN SPCNYDDKRY
RHGDVFSASY DPCLNCSCDN SIVRCVPMRC DTQTLPCQNP VRVGSGCCDL RCPECVDEGK
RYENRDVWVS SSDPCRVNQC REGRIITRTR QTCNRTCTHG TIRRNECCSS CTDCLYDGET
YSDGQSFMMP GDSLQRCACT AGNVNCRLIG PCPPIRCSVT ETPPGAVCPI CKGCSYNGQV
YQHGDTVSAS RCTILRCQEG QVLSERVQCA PPPCLNPAEV DGQCCPVCKE CSFEGRNYGE
GSTFPNPSKP CETCHCQRGE VRCRKTSVDT CPPVTCRYPE TRPGDCCPSC GGCHYLNRHF
QSGQKFVPPG GDACRVCVCE AGTVNCTRME CSPVSCPNPV RPAGRCCPVC PINCNVLGTR
YREGQSFGDT MDPCTRCTCW GGRITCQSHA CPSTGCTDPA RRTGQCCPSC SQCEYNNRLI
RNGQVYVDPA EPCKECRCTD GSITNVTVPC PPVTCDRPVT LPGRCCPVCE DNIPGPTPDI
TCEVGDVTYL SGATMPHPSD KCQECVCRQG RVDDCRQKSC AQSRCNSPVF TQEECCPQCT
DCNFEGLIHK SGRTFTHLLR RDQTCTCTRG NVMCECNQCQ PLTCSNPAPA NSTSCCPTCH
NCLYGNQVRI NGTQFPCGES CTTCLCVNGN IKSTPQSCSP VDCQHPVTDG CCQNCEQCSY
QGRTYSDGQR FSDPRNDCNL CMCDRGTVTC QAKSCPAPTC SYPSNGLCCP ECGNCMYPNS
AGRLIRNGHR VPSQQDVCTE HLCRNGEIAN LTKRCVGVSC QNPVTRNCCP ECTDCLYRGM
ERRNGESFKN PEDGCSSCQC VNGNVRCSRK TCNPVDCNCP AVKGCCPVCG DCFYRNKFYA
DGQNFTDPNE TCVKCECQQG NVRCARVSCP LLRCPENVQF YGSNRCCKQC PTPDHLVDCV
YEDQRYTPGQ TFPCGCDTCT CRRDGSLDRR RIDCPIALCN NPRTSDLCCP SCDSCELRHS
TDLQRTLILP DGQQREDPGD TCTTIICEKG NIARVSRSCY VQCTHAIPPS LGKCCPECTD
CIYRDSTGAE QIIRHTQTFS DPGYPCRDFS CLFGNVTQRQ KMCDFVPCDN PTTDSCGCDV
CDSCLYNGIS YTDGEIFNHL FDSCQECECK KGTVECQSVQ CVDSCTHPAD VTDCCPSCTN
CYYDGSIRTN SMNFVSSDCK QCVCVNGNVN CQNLVCPPLT CTNPVQIQGD CCPICRDISP
TVPVCTFLGE RYEEGTAFKH PEDGCRTCTC RLGRVSCQDP VCDIRCEHPR PDTCCPVCDD
CLFEGQLYPN TMSFQPDTCR NCRCDEGTVT CQERTCPDLG CAQTMKVPGQ CCEVCSGCEH
KGERYQDGQQ WRMVANLCVT CSCTAGLITC MEMQCFNTCD NPVNVPGQCC PVCPSCRYNG
LSYTDGQSFS PNGDPCDICT CESGGLKCHH ESCPQIANCP VEQQLAAGPG QCCPTCSGFG
TNCTRETVGV SLRPRATQDP CVVCECTASF HWMCTTQRCN PVACPPSVQR VQSGQCCPQC
PACYDTREDR YYEEGTTWAD NSDPCMVCRC QGGEISCVAV DCPRVFCLDD QVPLPSPGTC
CPVCQNIDRA ECVYQGNTYQ TGDVWTIDEC TTCNCLGGTV SCTTEQCDQE TCGFDATLSR
IPGQCCPVCQ TSPATCLVYG DPHYQTFDGT SISFMGNCRY LMAADCENDD FIVEVQHDRR
SAPLAVSWAQ NFTVKLSGYK IDLLQDGIVM VNGRVIQPNY RQGSVFSVEI KDGTVFLNTQ
IGVKLVWNGA SQAELSVPGS YKRKMCGLCG NFNGYPQDDM RTRSRQITNS PSIFGNSWKA
DDQTSDNCAN ADDIDPCKEV GYRGKRIAET KCAILNGPAF SRCHRTVSPE PFYAACRHDM
CVCLDNDTCL CEVLSSYARE CAKKGIRLAW RSGGLCEFSC DVSKGFVFDE CGPVCARTCE
NFDQPTADLS SKCYKPCVAS CQCPANKVLY NGRCVDSTSC PNINRAFSGT TNTRIP
//
