ID A0A210Q0P3_MIZYE Unreviewed; 209 AA.
AC A0A210Q0P3;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Metalloproteinase inhibitor 2 {ECO:0000313|EMBL:OWF42324.1};
GN ORFNames=KP79_PYT11955 {ECO:0000313|EMBL:OWF42324.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF42324.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF42324.1}.
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DR EMBL; NEDP02005296; OWF42324.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210Q0P3; -.
DR STRING; 6573.A0A210Q0P3; -.
DR EnsemblMetazoa; XM_021514583.1; XP_021370258.1; LOC110461210.
DR OrthoDB; 5403389at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd03577; NTR_TIMP_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF33; TISSUE INHIBITOR OF METALLOPROTEINASE; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..209
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012374497"
FT DOMAIN 23..156
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT DISULFID 23..105
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 25..131
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 39..156
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 209 AA; 23108 MW; F0D899788BAD9737 CRC64;
MIYQGLIVTV GVIVTLNALQ ISCQCLECPT KTHPQDAFCQ DDFVIRTTIT DVTEVDPKTS
YKIDIVKVFK EPAVPSIVPT CVPSGLSVPP ECFFSLHVLN ASLPCGVELE VGQEYLISGT
EEDGEMIIDA CSLAIPWEEV TSHMKIGLNK RYKKNCQCQT GEDNCIVEPP EDELCFCQYA
TCVEVKKDDC APVCKWKKSK TFKTCVEGP
//
