ID A0A210Q1L4_MIZYE Unreviewed; 571 AA.
AC A0A210Q1L4;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Malate dehydrogenase, cytoplasmic {ECO:0000256|ARBA:ARBA00019899};
DE AltName: Full=Putative malate dehydrogenase 1B {ECO:0000256|ARBA:ARBA00039310};
GN ORFNames=KP79_PYT04875 {ECO:0000313|EMBL:OWF42631.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF42631.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000256|ARBA:ARBA00009613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF42631.1}.
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DR EMBL; NEDP02005240; OWF42631.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210Q1L4; -.
DR STRING; 6573.A0A210Q1L4; -.
DR EnsemblMetazoa; XM_021513943.1; XP_021369618.1; LOC110460791.
DR OrthoDB; 2897329at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23382:SF1; MALATE DEHYDROGENASE 1B-RELATED; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000242188}.
FT DOMAIN 159..280
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 291..461
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT REGION 487..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 63529 MW; BB42A0DDBF33BA0F CRC64;
MAKVVIAGKA DCPYYARCEL LGDKLAKNLP DFCLHKIVKQ NDEWEKWLKA TCNERGWTHM
KSPIVWRELI DRGGKGVLIG GANDFQEYAH GYYGMESELL SSDMLKISKE NLQYKKEVDE
EEKEFKAQSK PLHVCLTVAS NPACYAMVNA ISKGDVFGSK QEVALHLYDA NDKMEMLEGL
RMEAIDLAHG LLRDVTVESN LCKAFSNCSA IILMDEVVRN EGEDKDSWYK RNSNLFCNYA
KIINDVARKN VKVLLTGDGP VNFNVFMMLQ NAPNIPRQNF AGLSRMLENH TKAVIADKLK
VNSSGVVNVV IWGNVSGEYY IDLETSRVHG YEGAIWGPPS FSLPTKEMIW DKQWLAKEFP
ELVKARKAMV EEALNHGAYM SKGAAIATML GHWWTGSPSG EIFSLAVCSE GWYGVPDGLV
YSFPVTMHPK GYWYVVEDID LTEEVKETLK VTVQDLISEK EIMYPPPKPP TPPQGEVKVT
IMEPKEVAAA SEKEEEKKEE SGEEGSTPGT ADSAVEVDSS NEPKLETIVE EKGANDNVNG
NATVADRSAN EEKVDDSAQE AEQTTPAENA E
//
