ID A0A210QB89_MIZYE Unreviewed; 1719 AA.
AC A0A210QB89;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Protein unc-13-like B {ECO:0000313|EMBL:OWF45986.1};
GN ORFNames=KP79_PYT15440 {ECO:0000313|EMBL:OWF45986.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF45986.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF45986.1}.
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DR EMBL; NEDP02004329; OWF45986.1; -; Genomic_DNA.
DR STRING; 6573.A0A210QB89; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 605..655
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 711..839
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1147..1290
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1400..1532
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1547..1674
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 168..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1449..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1719 AA; 196367 MW; FF1856FEB185F89E CRC64;
MSLLCVCVKK ARLLGNAAAE EERFNTYVTL KLQNVKSTTI QVKGNNPCWE QDFMFETMRL
DTGLIVEVWN KGMLWDKLLG LHWLPLRKIH HSNTEGDGAW LSMYSELILQ NGEVAGTRVK
TGHEILIDAR FELPYDVVAD LPETEAVELQ NKLEVLNTMD QEILTIQEQH RRHTSSTQSG
MSEDSDYTSD ISFPQQHQHN SSVHQWRGTT DPLIRMREDS REEYMRDMGP FDSFDGESFE
RGGSFDRIEN FDQDRMSDTE RTFGHVDSFD RHLSGGESIE REDYDQDKYV YDQDEYYQDS
PYQNSQDGYN NDSPYHNNDG FRDGSYGQDS PYHQSQDSPY RKSRDNFQDS PYRHSRENSQ
SQDSNSESVY RGQSLDNYQD YRQGPGQDGP RDSPYHQVRS DTDSDLLSYN SRPQQPYKFL
TEGSPIRSRD SLTNMTNMTT TSRHSTQDFS PANSQSSTTN VSRQSTQECS DESAAFERSS
NLNINSPAKA KWIDVYNKVC VKLGQPGTLM DGDVSDDHGH GIQHNGGPPE HNPFYTSIDS
MPEIRAPRRK SVSLVSDLTM QVKNRNAGVP SAMVARQSLK DEELKMHVYK KTLQALIYPI
SSTTPHNFVV WTATSPTYCF ECEGLLWGMV RQGVRCTECG VKCHEKCKDL LNADCLQRAA
EKSSKHGAED KTHNIIMAMK DRMKIRERNK PEIFDLIREV FGVDKKSHSG HMKAVKQSVL
DGTSKWSAKI AITVICAQGL IGKDKTGTSD PYVTVQVGKV KKRTKTVPQD LNPVWNEKFY
FECHNSSDRI KVRVWDEDDD IKSKLRQTFT RESDDFLGQT IIDVTTLSGE MDVWYNLEKR
TDKSAVSGAI RLHISVEIKG EEKVAPYHVQ YTCLHENLFH YLCELAAGAV KLPDAKGDEA
WKVYFVEPSQ EIVDEFAMRY GIESIYQAMT HFSCLSTKYM CPGVPAVMST LLANINAFYA
HTTASTAVSA SDRFAASNFG KEKFVKLLDQ LHNSLRIDLS MYRNNFPASD RARLQDLKST
VDLLTSITFF RMKIVSNPDV QELPSPPRAS TVVKDCVIAC MKSTYQFLLD NCYELYQREF
QTDPAEAEAD QQGGNANSLD LLHKLITLIV SVIEEDRNSY TPVLNQFPQE LNVGQVSAAN
MWALFSQDSC YALQEHEVER SCKSSEYMNL HFKLKWLYTK YIADVPQYKG TVPEYPQWFE
PFVMQWLNEN DDVSMEYLHS AYERDKKDGF QKSSEHSLFS TSVVDVFTQL NQCFDVIKKL
ECPDPEVVKR YMRRFAKTVN KVLLTYADTE KKDFEKYTNN NRVACILMNN IQQLRVQLEK
VFESMGGEKL DTEASQMLKE LQQKLNTVLD DLAMIFAKSL EPQIQQSMQE LGTLLSKVKG
AGQVSLAQPS QRNSIQQESD MVLGPLMDLL DGSLTMFAQL CEKTVLKRLL KELWRIVIYT
MEKKVVLPPL SDPRQEKGSK SDVRDMSKEA EKNLSPKQCA VLDMALDTIK QYFHAQGKGL
KKTFLDKSQE LQSLRYALSL YTQTTDTLIK TFVSTQTSQD QPSNEDPVGE VSVQVDLFTH
PGTGEHKVTV KVVAANDLKW QTSSMFRPFV EVNLIGPHMS DKRRKHSTKS KSNNWSPKFN
ETFHFILGNE DDPDAYELHI CTKDYCFARE DRLIGVAVMQ LRDIVEQGSC ACWCSLGRRV
HLDETGWTIL RILSQRTNDE VAKEFVKLKS ESRHLEEVS
//
