ID A0A210QD68_MIZYE Unreviewed; 1089 AA.
AC A0A210QD68;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=KP79_PYT17692 {ECO:0000313|EMBL:OWF46670.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF46670.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the Deltex family.
CC {ECO:0000256|ARBA:ARBA00009413}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF46670.1}.
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DR EMBL; NEDP02004108; OWF46670.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210QD68; -.
DR STRING; 6573.A0A210QD68; -.
DR EnsemblMetazoa; XM_021505549.1; XP_021361224.1; LOC110455419.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd09633; Deltex_C; 1.
DR CDD; cd02907; Macro_Af1521_BAL-like; 1.
DR Gene3D; 3.30.390.130; -; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039396; Deltex_C.
DR InterPro; IPR039399; Deltex_C_sf.
DR InterPro; IPR039398; Deltex_fam.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12622:SF44; -; 1.
DR PANTHER; PTHR12622; DELTEX-RELATED; 1.
DR Pfam; PF18102; DTC; 1.
DR Pfam; PF01661; Macro; 2.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00506; A1pp; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF52949; Macro domain-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51154; MACRO; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 264..453
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 524..715
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 908..945
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 217..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 120783 MW; 3F16C1E268E7497A CRC64;
MFKCNICRSG GTHQDVAELN YCTAMATEEP METEVFGGSQ GTNPSTHHTS FATAQCVPPP
RWTFSGLELI LLLYFCKKSF DQLVKFKYVE LRQQIGILHV YIIKDDSTKY VEAEFKSMNL
FLNDLIKNEI SIPNDVLLHR KKKLQEYVHK NNGQPEHRCF LHLSDDSRTC TLFAKRRDTD
LYQFRLKHQI DDWMTDIKRS VPEAISYPHP NMNTVANDTH LTSSRRPPSY ADSVRTNPKT
VPANYQGSTT LGSSQNRHVA SSSFSSPPMF SYKGLDVHTV HGSITKMKTK VDGVINAAND
RLDHIGGVAF YIAEAAGERM EEHCKEIMKK TKKIAVSENV VTTAGRMRCK GIIHAVGPKW
GDYQDKHCLD LLADTVEKAL ITAEKEYYSE VAMPAISAGI YGIPKSLCAA MYIKGITQFC
RKPKSVSWLT SLYIVDISDD ILNEIQKAYS NWEKDKKSIE PSELLKQESL VRPRSAFSKS
MSLRGSAAGV GGNVTTFSGK GSSPLHEQQW TKGPDESIPG LMDKVRCYKT DDGSFCVKIY
TGSITKVKSL DAIVCTADTS LSGLGPLSEA VADAGGYRYN SSFSSQKQKY HSKAIKGQAF
VCSAGHLAVT HVVHIVIEQL VDTQHQSLID YKNFILNGLH SMSGWKMRSV ALPLLAGGFV
QHDKGSIRKM CDILYEAVMD FRLKSGPGRS LREIHFVNRK PEITQAFVDC FNQHLSSIKK
TPTGPAPSAG AGKSTKKLQH GEANSFSESS YGTKLKTHRG QGEVGNWASV KQGQRHTQSM
ILPKKTSSDG GTYNKAIDDL GFLSTNGGGP NFRGNKALVK NELREEEENL QLKEKCKTQK
PVVRKRIQKN ICAACDTKLE SDNVSRLACG HSFCSIPCFI PMQNNPSCAI CKEVEGATAA
ESEEDVTCVI CMDTITDQKK LSCGHVFCGD CIMQSMAHKP ACPVCGKIFG ELEGDQPTDG
TMTVTRNTHH SLPSYEAYGI IEIKYKFQDG IQQENHPQPG KPYKGTERRA FLPDNREGQK
VLRLLQKAFD SRLTFTIGSS RTTGQEDVVT WNDIHHKTKR DGGAAKFGYP DPTYLSRVQD
ELAAKGITE
//
