ID A0A210QGZ7_MIZYE Unreviewed; 1595 AA.
AC A0A210QGZ7;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=CD109 {ECO:0000313|EMBL:OWF48040.1};
GN ORFNames=KP79_PYT13953 {ECO:0000313|EMBL:OWF48040.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF48040.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF48040.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NEDP02003738; OWF48040.1; -; Genomic_DNA.
DR STRING; 6573.A0A210QGZ7; -.
DR EnsemblMetazoa; XM_021502607.1; XP_021358282.1; LOC110453604.
DR OrthoDB; 2970602at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF179; LD23292P; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1595
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012758430"
FT TRANSMEM 1565..1587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 488..623
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 764..857
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1450..1541
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1595 AA; 182820 MW; 0F95BD6DD9B987E8 CRC64;
MIRFLLLGAA LLGVGYAQSR QTVIDNQVGY KQERAPTYLV IAPKRIRPNQ VVQVFVTILK
LEYSRINVRI SITHKKVEYA SAELAFEQIG SRTIQLHMPQ NSQTGDYKLR VEGTIDGGSS
GNVFENETSI EFFPKQASLF IQLSKPIFRQ GQKVYFRVVP ILPNLMPKYG SMTIYVNDPT
GFPVRRWLAV QTNAGGILSQ SFELSDQPNY GNWSIQVDAF GFVYHKHFLV EEYWDPRFDV
NMTVKPYIMD NLATVGGVIS ANITTGKPVE GNATVVLSVK PPPDPRYLNT DVTNTNPALR
IPIMITQVYD YVKGPIAFNF NMADILERVR RYWPQYVGWT ALTDFELQFN ASVYDWFYSM
TKEGYASTTI FSSRTRLQWI GDQVRTFKPD TVMSVQVAVM KYDGTPVTST KYVRLTLEPR
YSTGGGGGTP VFTGAQFMKT PVKGIVQFSI PVDKQLSALK LTAQYDGDPS TEIKLMATKF
YSPSNSFITV STSTKTPKIN EYMIFHVRTS NYIPRIYYQI VAGSNIIVGE ELEMKSRRKT
FSIALSIEMI PTARIVVYYV SGQPEEIVID TLTFSIDGMK SNQVGAKINR GKDFTRDTVE
IMATSDPGSY MAFAAMPSDL YARGINDGLT EYNLVDELNS YDAPARGSYQ HLWRLSETEY
QYTFFLAQGY GIDSFTTFRD SGLLALSDVT ITRVPNQCEF EPETIPCFDG TCYHKNKTCD
NTFDCPSDWS DEENCPKEDP RFNNKTTNMI NRVSRVLRFY EDSSWAWKEH FTKPDGEVDF
RVNVPKYPLN WVINGISMSR SLGLGLMSKP LRYDATRYMY IIVESATHII RGEQIGVRVT
VFNYWYSSDF IEVLVTMEGS PDYDSVLVGE EGFVTSYSPT RHNGDHQTIV FLEPGESKDI
LMPIVPNMVQ GNFTYTVSAW CFLERDSVTK QVYVKSDGVL NYYHTPCLID LITYGSIIIP
DLKVNVSDQF ITPEQRYHNY VPGSGVGHLS LFGDVVTPGF FVDYPTAEDI MYRPYGAGEM
NMFNFAFNLI TLKFKKANQQ LPNHILKRTL SYMNIGLQRQ LSYMKEDGSF KMFRDDNRSS
TWLTAFVAQT LHEARFGEWE KDLFIKLELI NKIVVWICEK QNNVTGEFYD DQVPVYDRNY
ASRSDMMQAK LTGHPVPLTA YVLIALYKIT DVSQEAQSCI EKARQRASEY LSTRTSEIEA
SNEIFHMAIT AYALSLSQQR SRTIFDKLWA KRKKAEEFYF ADDVVRENPS DFVNTVRYLK
PRVELMNDAH AVQSTAYALM AHINHFGSSS GDYKIQRDSM MRWLQTMRNY IGAFASSQDT
LAAMEALYAF TQVDPNRNVF DVYMELESSA SPEWETLMMM TKYNYTDLQE VFLPKVYGQV
RVTAKGTGRA LMQLTTTVNV EYAWQIKNTV DSKQFYLLDL DYLHFSGRNF STMEMMPCVS
WIYTEKSVTS GLSVLEIDMP SGYVVMNDTL RSLVLNNTVR NLQRAEFYNR KVVFYFDYLD
QSRSCVRFKA HRWYPVANMT IQHKMRLFDY YEPGLHNTTM YTTYNLFNLN ICYVCGSYQC
PYCPFFNVAT ILKASFTMVT LIMGFFIKRY MLRVT
//
