ID A0A210QH97_MIZYE Unreviewed; 849 AA.
AC A0A210QH97;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN ORFNames=KP79_PYT03797 {ECO:0000313|EMBL:OWF48112.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF48112.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF48112.1}.
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DR EMBL; NEDP02003722; OWF48112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210QH97; -.
DR STRING; 6573.A0A210QH97; -.
DR EnsemblMetazoa; XM_021502494.1; XP_021358169.1; LOC110453520.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09919; SH2_STAT_family; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 616..738
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 768..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 98185 MW; D2F0804F840519B4 CRC64;
MSVDEEKSPV SEMELNMPRT PVFEKSRSLW GHVKMLPLQI QRQLLDQYRD PFTVEVRDKL
ADLIEQLPWS EVNEENSGNV EDEGYANQML ESVLNKLSET IHSTTEFVLK TKLRDSEHKL
RQRYMGNALE FVKLVKSYLS QEERAVAQAE NATSADGGDT QYHRQIDLIQ RIESLQGRTQ
VTQNYLQTLD EKFKQLIITR QKHSQIKVQT QQVENQLHNI QNTSGSMASD IYQQNLMVCM
NQRTNLTRMS QDINHTIKDM ASQLVQIRLD FTENFQKTHS ELEVLQQLVD QEVLSWNRQQ
RLAGNGAEFD TRALATIQNW FEGLADLTWK NRNQVSQMES FGQDFPIDVP QGIQDIVSRL
RGSVNNILTG LVRSAFIVEC QPPQILKVNN KFTAKVRLML GNKLKIYMDP RKVTAVLLSE
RQLSRLQECE NPHLFKENSG KLLNDNGRME YNETTREHSV SLKSMQLQKI NRADRKQNVT
EEKFCIVFKS TFQIGNQEQF VWTKSNPIVV IVHGSQECRA MATIMWDNQF AIPERQMFEV
PDFVPWPQMC ELLSCKFKQM TQRGLGKNDL DYLAHKIFQG GRDIVDYSPY SITWAQFVKE
NQQLASGTVS FTFWDWFHSI MKLTRKHLRE LWQDRCIVGF ISRSKAEQQL LSVDNGNFLL
RFSESELGGI TVGWVDDVAQ QQGDENEVKR EANFAQPYEA DDFCVKSLAE RIKDVDKLVY
LYPNRPKEQV FKKYWLPFPG RNSKKPHNPR YKHMGTLIQD IIAVPTQTSS VSRKREKTSE
NEEEMTMEPA SEIGSKTAMD DMSGFGSVFD NTLNVEQIMN AMDIAHVSSP DSIQIDAFDE
LISEDDDIL
//
