ID A0A210QL67_MIZYE Unreviewed; 2248 AA.
AC A0A210QL67;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Protein very KIND {ECO:0000313|EMBL:OWF49470.1};
GN ORFNames=KP79_PYT17546 {ECO:0000313|EMBL:OWF49470.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF49470.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF49470.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NEDP02003088; OWF49470.1; -; Genomic_DNA.
DR EnsemblMetazoa; XM_021499822.1; XP_021355497.1; LOC110451693.
DR EnsemblMetazoa; XM_021499823.1; XP_021355498.1; LOC110451693.
DR EnsemblMetazoa; XM_021499825.1; XP_021355500.1; LOC110451693.
DR EnsemblMetazoa; XM_021499826.1; XP_021355501.1; LOC110451693.
DR EnsemblMetazoa; XM_021499827.1; XP_021355502.1; LOC110451693.
DR OrthoDB; 2919695at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR029899; KNDC1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR21560:SF0; KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21560; VERY KIND PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00750; KIND; 2.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS51377; KIND; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 99..284
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 473..637
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 1756..1885
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1962..2225
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1447..1554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2248 AA; 248773 MW; 1EF4382959801AF5 CRC64;
MESPKDTKEA GNHHDEEEDF LPEEGGYEYL DSHVTGECSN ENDQEYTTQG ELLAGLQKDQ
LPPLLQDENL NEYDRRDGNY YDDEDVDSLA GLNEADEAVN LADILAARDT SLVEDELWAL
CRECCLVLEV VNCTPEMFQT LCITPDTVAF DNAGNVCFLD LGSDPEPLYL PPEFSNVANN
YKSHLYSLGM TLLYAAEYNV EPGRPEITPE LRDLFGCMTA EVLTARPSLE DIITLCEEEL
IGKSSQEICV DIAQTFALPT PTPPDLATVS LADVTASLAN YLQTQSNLIS TPAAEVCGNT
GDTEGREVST NSPPGPLEHS TPLHLQAPPQ GQTTTPPTEQ TEDEDMPVRG LHTGVPMPTG
NRGNRPTPAA RKSSRSSQDS YKEGSQQKPP VAKKPDLNKV VKSSDMTEGC DSTGTNQSDN
QKMQHGENTP LHREGSKFKD SPLSGAVNSS LEARHSSGAV DSQGKRPRKN KGLSLSNILE
TLERPLVEDE VWAVCREGTI SLNKKRKHLP AYISPDTLLL RESGALAFKA IPEDKPLEVI
YMAPEIQQKG QLSDKMCLFG LGVTMRYAIG NKYSTESSGV GDELQDLLAK MVEEDPEKRP
SIEDVSEVCG EHEGELGIPS SSICQALYQE AFERLADKMA FAMPSDPPKI QDPPQLSNGS
AFRSIQGGSL IRPAAINSST AAFKPISNLP EGKGHSGLPS QFMSTATHFK PIILQQSVTP
APEVTEVAKQ QMSPKDCQPN DKDKEVVKKL KELKKNLMQH RQPGKDKADG KVSRKSSKSP
AASPKTSKVT STKPSEDTSD VNSKTSSDTK SETSGPLESL LTEIQKQGAV PNTQALASAI
ANFLQGQMAQ SPNQNTPNVS QGQLQDQPQV EPQRQGQIPG QQNSVIQGQT QIASPLSNTA
MPSMNAQQQN INIPTQYQPS LIGQNSSVPI GPQQYSGGLM PGYPLQVQLQ QDPRTGFIQL
VPTGILPQAI GPLIGDDHPH SGSNCDNHSV RSVRSPKQHI YSDNSSADNS AILNSSFNSN
RSRGGHTARD LVQKTTGFRT LHSQGKASPL SSQPQGDYLW RSKSAHALDT LEGEQGIEGQ
ASQRGTMSLA PGHIYDDSVL TTNRRGPNRN VNGDMYSQSS KLNTGPRPRT IVGYPEDGPG
RQYFTQPPRT RSQSSSPSPS KDSGVSGMNT GYKPPPPGSL MERLLSNVNV KQQQKLGQVV
HLLREEFAFD GYMENGVEDI AMAEYITSLG NLKLDTFASA VTEKYSDLYW GSDLLFNLYD
AANGLKGSRR LMKNSAKLYD QSPLSKRQSP SAQLPMPGLE DQDPNLSSSS PSDSGLPQTP
QKLPADSAYQ QSVSRQQDKQ KHRHLSVQQK SQHRNTSDSS DTEQFDRRRR YRRKQHTDKS
RNNQEYTLRT SGYDTPSMEL HPLRRDTDIS PRLQMHMANG ENPLLQNGTV QVPQIRDWDL
DIAKASHTNN PNSLIQDEEK VSDVVSEKPP PSQGRQNAWV ASPDKTDEFA STSTDRQRKP
MPDSSIMSST RQVLASNSAP TADMSKLKRR VTPEKPPRHS LVLNNRPDGH VQPGPKPLKA
VHRDGSTSSH SSEVAEVLPV TNLSRNMSML SLDNNPGDAH LRNRKGHVVF HSAMMELFSS
PELDKFRQEI DEDDPAGLQS QLNAIQQQLM MERKMKRKSQ TFYSKLVESP KAVKSDQKNR
MTQVSKDLED MTQKTRFLEL CKTHIEMLQA ELSGIHVSYL HSLATCPKGQ PLHLRPCQEN
PFLQFQHPKE PQTGYEILSL QSGTPEGLMS YLFANAALRD GYIHQFMYCF RYLVRPVKLL
SFLVDAYKAA AESTGQSNDN NMSRIQQRVM DLIYYWLEGY YSVDFERNNE ATELLHAFLQ
LSDIAALPEG KELKESLSNC EEGYSIDLVS AKEEEDIHIY KANTPRKWGS LKNILGRGKS
TSPKLTLFHE KRTPVTKLTT DDGFLPAKSP RRVDSFTLLD HTPQTLAEQL TLIAQSIFQL
THPVHYLNSK AQGISVAMTM TGSKTPLMQR LTGQDSDQPL PPSLFENKTL RETAVQLMIE
HDQEVGHWVA AEIVNCSNPK NQLAILTKFL NTAQICKDMR NYGTCLAILD GLENLIVKQL
PAWRHLQGKC VSIIEELSSV RLFLKNDGMA ITSVTNSHLL PTIPSVLLFL FHVQQQEFGS
FQLANGMYKW SKIRSISKII DQIRIFKGHL YGFEPDFDLQ DDLQLRIREF GGQDIHQIAA
QHHTNYQKMP SGGISGAFRK MKGRLQSK
//
