ID A0A210QNS9_MIZYE Unreviewed; 816 AA.
AC A0A210QNS9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10 {ECO:0000313|EMBL:OWF50393.1};
GN ORFNames=KP79_PYT09454 {ECO:0000313|EMBL:OWF50393.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF50393.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF50393.1}.
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DR EMBL; NEDP02002617; OWF50393.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210QNS9; -.
DR EnsemblMetazoa; XM_021498042.1; XP_021353717.1; LOC110450489.
DR OrthoDB; 5395001at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR PANTHER; PTHR45702; ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER; 1.
DR PANTHER; PTHR45702:SF2; KUZBANIAN, ISOFORM A; 1.
DR Pfam; PF13574; Reprolysin_2; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Integrin {ECO:0000313|EMBL:OWF50393.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..816
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012239434"
FT TRANSMEM 686..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..464
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 464..567
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT COILED 725..755
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 397
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 396
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 400
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 406
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 816 AA; 90357 MW; 969121220F46C9EB CRC64;
MFSRIVCHLF IILTAVNVLS VNCFHNIRST GKDRNTGSGD ENIRTFVKDY KTVLLNISNK
FTSSERQDYE YADKIIRFNA YEMNFTLVLH HDRSVLSPNL IVTMGRSAWS GGRLSAMGLA
AVFSGSVMGE KGSYVYGKLN GGTFDGMVQT KNEILYLEPL SKYSSEIVNG SNQICIIYKK
ADLVDQNPPD QFKLKENCHT VNSTGMQAPW VLNSVRKKRS RTRRAATFSH SCSLHVVVDH
LFFVGVGQSS RSQTIAEIMY LVGSADHIFR STDFNGDGKG DNVGFTVTAI SIYPNETVDD
YKTANSIDVY DYLNQFSKYN FDDFCLGIAF TFRDFKDGVV GLAWIGNSDV YGPPGGICQT
RINLSGKTFN FNTALVTLNN YGSRIPSYRS SLTLAHEFGH SFGSIHDSAA DASCSPGNDL
GNYIMFPYAA DGSSPNNNIF SSCSLSQIYP VIVNKGSCLN AETGPVCGNA IVEAGEECDC
GSSGLCTFYG DTCCVPSDVV FEVDRPCNFR RHQGKVCSWK FSPCCRQNCT YIPASDSHKC
AEASQCKQES LCDGTSGECP DGFFLLDGII CAGGKKACKA GVCVESICES RDMHTCQCTG
VDDHMCMLCC RSGNSTKCQP AHNFGLLGTF GEVLYQDAGA TCYNNAGVCD KKHKCMLNNP
DDVIKRLGKM FNEENLEDIK TWLANYWYYI VIAVLGIAIF IFIFIITKKK LDNTHVDAYR
MGRLLRVTEQ ANLEKERQKK QLEELDTKYT EKIQKVKEGA VQREFTEAVS RLVNLFPTAT
TGTIADLCRK CTSEDVAVRL LLVKGYPIKR MVTYDQ
//
